591239-68-8
Chemical Structure
ZINC05007751
- CAS No.: 591239-68-8
- Formula:C18H12N2O3
- Molecular Weight:304.30
IUPAC Name: (Z)-4-methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile
InChIKey: SNLNUUWCOAPJED-ZROIWOOFSA-N
SMILES: N#CC(C1=O)=C(C)/C(C(N1)=O)=C/C2=CC=C(C3=CC=CC=C3)O2
Biological Activity: ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1].
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ZINC05007751 | 99.33% | ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9. | ||||||||||||||||||||
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Keywords
