NEK9
NEK9 (also called Nercc1) is the upstream activating kinase of the NEK6/NEK7 module during mitosis. Activated by CDK1 phosphorylation and by autophosphorylation at the G2/M transition, NEK9 in turn phosphorylates NEK6 and NEK7 to trigger spindle formation, chromosome congression and mitotic progression. NEK9 localizes to the spindle apparatus and interacts with nucleophosmin and other centrosomal substrates. Beyond mitosis, NEK9 variants are associated with a skeletal dysplasia and with aspects of ciliary biology, and NEK9 participates in DNA-damage signaling. Recombinant NEK9 is a key reagent for reconstituting the NEK9-NEK6/7 mitotic kinase cascade.
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NEK9 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
