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Results for "

NFKB2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (6) Isotope-Labeled Compounds (2) mAChR (6) mRNA (1) NF-κB (2) Reference Standards (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Transcription Factors (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3229

SN52 2 Publications Verification	NF-κB	Cancer
SN52 is a potent, competitive, and cell-permeable inhibitor of *NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB* heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .

HY-A0024

Tolterodine (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583	mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder ^[2] .

HY-90010

Tolterodine tartrate Kabi-2234; PNU-200583E	mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine tartrate (Kabi-2234) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine tartrate competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine tartrate restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine tartrate ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine tartrate can be used for the research of urinary tract infections and overactive bladder ^[2] .

HY-RS09257

NFKB2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NFKB2 Human Pre-designed siRNA Set A contains three designed siRNAs for NFKB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NFKB2 Human Pre-designed siRNA Set A NFKB2 Human Pre-designed siRNA Set A

HY-174568

*Human NFKB2* mRNA**	mRNA	Inflammation/Immunology
Human NFKB2 mRNA encodes the human nuclear factor kappa B subunit 2 (NFKB2) protein, a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. NFKB2 can function as either a transcriptional activator or repressor depending on its dimerization partner.

HY-RS09258

Nfkb2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nfkb2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nfkb2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nfkb2 Mouse Pre-designed siRNA Set A Nfkb2 Mouse Pre-designed siRNA Set A

HY-RS09259

Nfkb2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nfkb2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nfkb2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nfkb2 Rat Pre-designed siRNA Set A Nfkb2 Rat Pre-designed siRNA Set A

HY-149351

NF-κB-IN-10	NF-κB	Cardiovascular Disease
NF-κB-IN-10 (compound E1) is an *NF-κB* inhibitor that can improve heart failure by reducing oxidative stress and inflammation by regulating *Nrf2/NF-κB* signaling pathway. NF-κB-IN-10 inhibits LPS-induced NO production and expression of iNOS and *COX-2* in RAW264.7 cells. NF-κB-IN-10 can be used in the research of cardiovascular diseases .

HY-A0024S

Tolterodine-d14 hydrochloride (R)-(+)-Tolterodine-d14 hydrochloride; (+)-Tolterodine-d14 hydrochloride; (R)-Tolterodine-d14 hydrochloride; PNU-200583-d14 hydrochloride	Isotope-Labeled Compounds mAChR Cytochrome P450	Neurological Disease
Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride . Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-A0024R

Tolterodine (Standard) (R)-(+)-Tolterodine (Standard); (+)-Tolterodine (Standard); (R)-Tolterodine (Standard); PNU-200583 (Standard)	Reference Standards mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine (Standard) is the analytical standard of Tolterodine. This product is intended for research and analytical applications. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-90010R

Tolterodine tartrate (Standard) Kabi-2234 (Standard); PNU-200583E (Standard)	Reference Standards mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine (tartrate) (Standard) is the analytical standard of Tolterodine tartrate. This product is intended for research and analytical applications. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-90010S

Tolterodine tartrate-d14 Kabi-2234-d₁₄; PNU-200583E-d₁₄	Isotope-Labeled Compounds mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine tartrate-d₁₄ (Kabi-2234-d₁₄) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library	1,670 compounds
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,670 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

NF-κB Signaling Compound Library

1,670 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 1,670 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P3229

SN52 2 Publications Verification	NF-κB	Cancer
SN52 is a potent, competitive, and cell-permeable inhibitor of *NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB* heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702972

	NFKB2 Protein, Human (sf9, GST) LYT10	Human	Sf9 insect cells
	NFKB2 Protein, Human (sf9, GST) is the recombinant human-derived NFKB2, expressed by Sf9 insect cells , with GST labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-A0024S

Tolterodine-d14 hydrochloride
Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride . Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Tolterodine-d14 hydrochloride

Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride . Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-90010S

Tolterodine tartrate-d14
Tolterodine tartrate-d₁₄ (Kabi-2234-d₁₄) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Tolterodine tartrate-d14

Tolterodine tartrate-d₁₄ (Kabi-2234-d₁₄) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (3) Mouse (5)
Application:	ICC/IF (3) IP (3) WB (5) ELISA (3)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86235

	NF-KB p100 Antibody (YA5927) NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NF-KB p100 Antibody (YA5927) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p100.

HY-P84451

	NF-KB p100 Antibody (YA4148) p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100	WB, ELISA	Human, Mouse
	NF-KB p100 Antibody (YA4148) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p100.

HY-P84451A

	NF-KB p100 Antibody (YA4148)(PBS only) p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100	WB, ELISA	Human, Mouse
	NF-KB p100 Antibody (YA4148) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NF-KB p100.

HY-P80763

	NF-KB p100 Antibody (YA269) NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10	WB, ICC/IF, IP	Human, Mouse, Rat
	NF-KB p100 Antibody (YA269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p100.

HY-P80763A

	NF-KB p100 Antibody (YA269)(PBS only) NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10	WB, ICC/IF, IP	Human, Mouse, Rat
	NF-KB p100 Antibody (YA269) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NF-KB p100.