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Isoforms Recommended:	NTPDase2

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NTPDase2

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By Targets:	NTPDase (16) Cytochrome P450 (8) Interleukin Related (1) Isotope-Labeled Compounds (4) P2X Receptor (1) P2Y Receptor (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Pyroptosis (1) Reference Standards (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (10) Cardiovascular Disease (11) Infection (1) Inflammation/Immunology (5) Neurological Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: NTPDase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100386

Ticlopidine 3 Publications Verification PCR 5332	NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively.

HY-103259

Sodium metatungstate Maximum Cited Publications 11 Publications Verification Sodium polyoxotungstate; POM-1	Phosphatase P2X Receptor P2Y Receptor Pyroptosis Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Sodium metatungstate (Sodium polyoxotungstate) is a *NTPDase* inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively . Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission ^[2] .

HY-B0153A

Ticlopidine hydrochloride 3 Publications Verification	NTPDase Cytochrome P450	Cardiovascular Disease Neurological Disease Cancer
Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-100386R

Ticlopidine (Standard) PCR 5332 (Standard)	Reference Standards NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine (Standard) is the analytical standard of Ticlopidine. This product is intended for research and analytical applications. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-103263

PSB-06126	NTPDase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the K_i values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC₅₀ value of 7.76 μM and a K_i value of 4.39 μM ^[2].

HY-120566

PSB-16131	NTPDase	Neurological Disease Inflammation/Immunology Cancer
PSB-16131 is a potent inhibitor of human *NTPDase2, showing non-competitive inhibition with an IC₅₀* of 539 nM. PSB-16131 can be used in the study of inflammation, neurodegenerative diseases and cancer .

HY-143289

NTPDase-IN-3	NTPDase	Cardiovascular Disease Cancer
NTPDase-IN-3 (Compound 5e) is a *NTPDase* inhibitor, with IC₅₀ values of: 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). NTPDase-IN-3 can be used in the research of cancers and thrombosis .

HY-143288

NTPDase-IN-2	NTPDase	Infection Inflammation/Immunology Cancer
NTPDase-IN-2 (compound 5g) is a selective *NTPDase* inhibitor with IC₅₀s of 0.04 and 2.27 µM for *h-NTPDase-2/-8, respectively. NTPDase-IN-2 non-competitively inhibits h-NTPDase-1/-2* with a K_m of 74 µM for *h-NTPDase-2. NTPDase*-IN-2 can be used in studies of cancer, immunologic disorders as well as bacterial infections .

HY-123549

PSB-6426	NTPDase	Cancer
PSB-6426 (compund 19a) is a selective human *NTPDase2* inhibitor (K_i=8.2 μM). PSB-6426 can be used in stroke and cancer research .

HY-155828

*h-NTPDase-IN-4*	NTPDase	Cancer
h-NTPDase-IN-4 (compound 4c) is a pan-inhibitor of NTPDase with IC50s of 3.58 μM (h-NTPDase1), 10.21 μM (h-NTPDase2), 0.13 μM (h-NTPDase3), 13.57 μM (h- NTPDase8).

HY-155829

*h-NTPDase-IN-5*	NTPDase	Others
h-NTPDase-IN-5 (compound 3b) is a pan-inhibitor of NTPDase with IC50s of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), 0.32 μM (h- NTPDase8).

HY-155827

*h-NTPDase-IN-3*	NTPDase	Others
h-NTPDase-IN-3 (compound 4d) is a pan-inhibitor of NTPDase with IC50s of 34.13 μM (h-NTPDase1), 0.33 μM (h-NTPDase2), 23.21 μM (h-NTPDase3), 2.48 μM (h- NTPDase8).

HY-155806

*h-NTPDase-IN-2*	Phosphatase	Others
h-NTPDase-IN-2 (compound 3l) is a pan-inhibitor of h-NTPDase, with IC₅₀s of 0.35 μM (h-NTPDase1), 4.81 μM (h-NTPDase2), 37.73 μM (h-NTPDase3), 10.32 μM (h-NTPDase8), respectively .

HY-100386S

Ticlopidine-d4 PCR 5332-d₄	Isotope-Labeled Compounds NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine-d₄ is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-B0153AS

Ticlopidine-d4 hydrochloride	Isotope-Labeled Compounds NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine-d₄ hydrochloride is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-W707554

Ticlopidine hydrochloride-d6	Isotope-Labeled Compounds Cytochrome P450	Cardiovascular Disease
Ticlopidine hydrochloride-d₆ is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-B0153AR

Ticlopidine hydrochloride (Standard)	Reference Standards NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine hydrochloride (Standard) is the analytical standard of Ticlopidine hydrochloride (HY-B0153A). This product is intended for research and analytical applications. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-RS04396

ENTPD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ENTPD2 Human Pre-designed siRNA Set A contains three designed siRNAs for ENTPD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ENTPD2 Human Pre-designed siRNA Set A ENTPD2 Human Pre-designed siRNA Set A

HY-166530S

Ticlopidine-d6 hydrochloride	Isotope-Labeled Compounds Cytochrome P450	Cardiovascular Disease
Ticlopidine-d₆ hydrochloride is the deuterium labeled Ticlopidine hydrochloride. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-181981

NTPDase/NPP1-IN-1	NTPDase Phosphodiesterase (PDE)	Cancer
NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC₅₀ values of 0.28, 0.92, 0.82 and 0.73 μM against *h-NTPDase1, h-NTPDase2, h-NTPDase3* and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer .

HY-103263R

PSB-06126 (Standard)	NTPDase Reference Standards	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
PSB-06126 (Standard) is the analytical standard of PSB-06126 (HY-103263). This product is intended for research and analytical applications. PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the K_i values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC₅₀ value of 7.76 μM and a K_i value of 4.39 μM ^[2].

HY-RS25355

Entpd2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Entpd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Entpd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Entpd2 Rat Pre-designed siRNA Set A Entpd2 Rat Pre-designed siRNA Set A

HY-RS18863

Entpd2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Entpd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Entpd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Entpd2 Mouse Pre-designed siRNA Set A Entpd2 Mouse Pre-designed siRNA Set A

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76903

	CD39L1/ENTPD2 Protein, Human (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2; Cd39l1	Human	Sf9 insect cells
	CD39L1/ENTPD2 protein, expressed in the nervous system, efficiently hydrolyzes ATP and various nucleotides, while showing limited hydrolysis of ADP. Its substrate specificity hierarchy highlights its regulatory role in purinergic signaling and selective nucleotide hydrolysis, contributing to precise control of neurotransmission. CD39L1/ENTPD2 Protein, Human (sf9, His) is the recombinant human-derived CD39L1/ENTPD2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P72730

	CD39L1/ENTPD2 Protein, Human (HEK293, His) Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2; Cd39l1	Human	HEK293
	CD39L1/ENTPD2 protein, expressed in the nervous system, efficiently hydrolyzes ATP and various nucleotides, while showing limited hydrolysis of ADP. Its substrate specificity hierarchy highlights its regulatory role in purinergic signaling and selective nucleotide hydrolysis, contributing to precise control of neurotransmission. CD39L1/ENTPD2 Protein, Human (HEK293, His) is the recombinant human-derived CD39L1/ENTPD2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72729

	CD39L1/ENTPD2 Protein, Mouse (HEK293, His) Ectonucleoside triphosphate diphosphohydrolase 2; Entpd2; Cd39l1	Mouse	HEK293
	In the nervous system, CD39L1/ENTPD2 protein crucially regulates purinergic neurotransmission by proficiently hydrolyzing ATP and other nucleotides. Remarkably, it exhibits marginal hydrolysis of ADP, emphasizing its specificity and significant role in precisely modulating purinergic signaling pathways. CD39L1/ENTPD2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD39L1/ENTPD2 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-100386S

Ticlopidine-d4
Ticlopidine-d₄ is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

Ticlopidine-d4

Ticlopidine-d₄ is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-B0153AS

Ticlopidine-d4 hydrochloride
Ticlopidine-d₄ hydrochloride is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

Ticlopidine-d4 hydrochloride

Ticlopidine-d₄ hydrochloride is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-W707554

Ticlopidine hydrochloride-d6
Ticlopidine hydrochloride-d₆ is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

Ticlopidine hydrochloride-d6

Ticlopidine hydrochloride-d₆ is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

HY-166530S

Ticlopidine-d6 hydrochloride
Ticlopidine-d₆ hydrochloride is the deuterium labeled Ticlopidine hydrochloride. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

Ticlopidine-d6 hydrochloride

Ticlopidine-d₆ hydrochloride is the deuterium labeled Ticlopidine hydrochloride. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively ^[2] .

ENTPD2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ENTPD2 Human Pre-designed siRNA Set A contains three designed siRNAs for ENTPD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Entpd2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Entpd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Entpd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Entpd2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Entpd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Entpd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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