1 Result for "

Nisevokitug

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Nisevokitug" in MCE Product Catalog:

Cat. No.: HY-P990009
CAS No.: 2649854-92-0
Synonyms: NIS-793

Research Areas:  

Cancer

Nisevokitug (NIS-793) is a humanized IgG2λ monoclonal antibody and an inhibitor of the TGF-β signaling pathway. Nisevokitug blocks the binding of TGF-β to the membrane-bound TGF-βR1/TGF-βR2 receptors, inhibits both Smad-dependent and Smad-independent downstream cascade signaling, downregulates fibrosis-related genes, and reverses the TGF-β-mediated immunosuppressive microenvironment. Nisevokitug can be used in the research of diseases such as pancreatic ductal adenocarcinoma, colorectal cancer, myelofibrosis, and myelodysplastic syndrome .
loading...
    loading...