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Isoforms Recommended: PanK3
Results for "

PANK3

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-44170
    Pantothenate kinase-IN-2
    2 Publications Verification

    		 PANK Neurological Disease Metabolic Disease
    Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes .
    Pantothenate kinase-IN-2
  • HY-124634
    PZ-2891
    4 Publications Verification

    		 PANK Neurological Disease
    PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively .
    PZ-2891
  • HY-144734
    Pantothenate kinase-IN-1

    		PANK Neurological Disease Metabolic Disease
    Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC50 of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases .
    Pantothenate kinase-IN-1
  • HY-159509
    Claziprotamidum

    Claziprotamide; BBP-671

    		 PANK Neurological Disease Metabolic Disease
    Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (KD = 97 pM; IC50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia [3].
    Claziprotamidum
  • HY-RS10018
    PANK3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PANK3 Human Pre-designed siRNA Set A contains three designed siRNAs for PANK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PANK3 Human Pre-designed siRNA Set A
    PANK3 Human Pre-designed siRNA Set A
  • HY-RS22708
    Pank3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pank3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pank3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pank3 Mouse Pre-designed siRNA Set A
    Pank3 Mouse Pre-designed siRNA Set A
  • HY-RS29222
    Pank3 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Pank3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pank3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Pank3 Rat Pre-designed siRNA Set A
    Pank3 Rat Pre-designed siRNA Set A
  • HY-181917
    Pantothenate kinase-IN-3

    		PANK Metabolic Disease
    Pantothenate kinase-IN-3 is an orally active PANK3-selective binder and CoA biosynthesis activator with a human PANK3 Ki of 9.1 nM, human PANK3 Ka of 1.8 nM, human PANK1β Ki of 113 nM, human PANK1β Ka of 23.4 nM, and oral effectiveness.Pantothenate kinase-IN-3 binds PANK3 via a water-mediated interaction between its sulfonamide NH and Gly193, elevates cellular, hepatic, and forebrain CoA levels, and shows improved metabolic stability in mouse and human microsomes.Pantothenate kinase-IN-3 has solubility properties favorable at pH 7.Pantothenate kinase-IN-3 can be used for the research of hepatic metabolic CoA deficiencies (acidemias) .
    Pantothenate kinase-IN-3

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