Pantothenate kinase-IN-2
Based on 2 publication(s) in Google Scholar
Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes.
For research use only. We do not sell to patients.
- Purity: 98.18%
- CAS No.: 902614-04-4
- Formula: C21H21N5OS
- Molecular Weight:391.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-diabetic Compound Library
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Highly Selective Inhibitors Library
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Publications Citing Use of MedChemExpress (MCE) Pantothenate kinase-IN-2
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Biological Activity
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PanK3 25 nM (IC50) |
PanK1β 70 nM (IC50) |
PanK2 92 nM (IC50) |
Pantothenate kinase-IN-2 (Compound 7) potently inhibits purified PanK1β, PanK2, and PanK3 isoforms with IC50 values of 70 nM, 92 nM, and 25 nM, respectively[1].
Pantothenate kinase-IN-2 binds specifically to the ATP-PanK3 complex, with an apparent binding constant of 0.3 μM[1].
Pantothenate kinase-IN-2 (0.5-8 μM; 24 h) inhibits de novo CoA biosynthesis in cultured C3A cells with an apparent IC50 of 0.9 μM, without reducing cell viability[1].
Pantothenate kinase-IN-2 inhibits PanK3 and PanK1β in a luciferase-based enzyme assay with IC50 values of 0.36 μM and 0.14 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 902614-04-4
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Appearance Solid
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Molecular Weight 391.49
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Formula C21H21N5OS
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Color Light yellow to brown
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SMILES
O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Redox Biol
Protein CoAlation is regulated by and integrated with growth factor signalling and the cellular antioxidant response. [Abstract]2026 Feb:89:103962. PMID: 41371167 -
Solvent & Solubility
DMSO : 12.5 mg/mL (31.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.19 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5543 mL | 12.7717 mL | 25.5434 mL | 63.8586 mL |
| 5 mM | 0.5109 mL | 2.5543 mL | 5.1087 mL | 12.7717 mL | |
| 10 mM | 0.2554 mL | 1.2772 mL | 2.5543 mL | 6.3859 mL | |
| 15 mM | 0.1703 mL | 0.8514 mL | 1.7029 mL | 4.2572 mL | |
| 20 mM | 0.1277 mL | 0.6386 mL | 1.2772 mL | 3.1929 mL | |
| 25 mM | 0.1022 mL | 0.5109 mL | 1.0217 mL | 2.5543 mL | |
| 30 mM | 0.0851 mL | 0.4257 mL | 0.8514 mL | 2.1286 mL |
Pantothenate kinase-IN-2 Related Classifications
HY-44170 Related Classifications
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