2. Metabolic Enzyme/Protease
  3. PANK
  4. Pantothenate kinase-IN-2

Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes.

For research use only. We do not sell to patients.

Pantothenate kinase-IN-2

Pantothenate kinase-IN-2 Chemical Structure

CAS No. : 902614-04-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Pantothenate kinase-IN-2 Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Pantothenate kinase-IN-2

View All PANK Isoform Specific Products:

View All Isoforms
PanK1 PanK2 PanK3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes[1].

IC50 & Target[1]

PanK3

25 nM (IC50)

PanK1β

70 nM (IC50)

PanK2

92 nM (IC50)

In Vitro

Pantothenate kinase-IN-2 (Compound 7) potently inhibits purified PanK1β, PanK2, and PanK3 isoforms with IC50 values of 70 nM, 92 nM, and 25 nM, respectively[1].
Pantothenate kinase-IN-2 binds specifically to the ATP-PanK3 complex, with an apparent binding constant of 0.3 μM[1].
Pantothenate kinase-IN-2 (0.5-8 μM; 24 h) inhibits de novo CoA biosynthesis in cultured C3A cells with an apparent IC50 of 0.9 μM, without reducing cell viability[1].
Pantothenate kinase-IN-2 inhibits PanK3 and PanK1β in a luciferase-based enzyme assay with IC50 values of 0.36 μM and 0.14 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pantothenate kinase-IN-2 Related Antibodies
Molecular Weight

391.49

Formula

C21H21N5OS
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (31.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5543 mL 12.7717 mL 25.5434 mL
5 mM 0.5109 mL 2.5543 mL 5.1087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (3.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5543 mL 12.7717 mL 25.5434 mL 63.8586 mL
5 mM 0.5109 mL 2.5543 mL 5.1087 mL 12.7717 mL
10 mM 0.2554 mL 1.2772 mL 2.5543 mL 6.3859 mL
15 mM 0.1703 mL 0.8514 mL 1.7029 mL 4.2572 mL
20 mM 0.1277 mL 0.6386 mL 1.2772 mL 3.1929 mL
25 mM 0.1022 mL 0.5109 mL 1.0217 mL 2.5543 mL
30 mM 0.0851 mL 0.4257 mL 0.8514 mL 2.1286 mL
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Pantothenate kinase-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pantothenate kinase-IN-2902614-04-4PANKPantothenate KinaseC3A cellsATP-enzyme complexespank-associated neurodegenerationtype ii diabetescoenzyme APanK3luciferase-based enzyme assayCoA biosynthesisPanK2PanK1βInhibitorinhibitorinhibit

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