4 Results for "

PTP1B-IN-2

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "PTP1B-IN-2" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-100462
CAS No.: 1919853-46-5
Purity:  99.80%
Target:  

Phosphatase

Research Areas:  

Metabolic Disease

PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
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3
3 Cited Publications
Cat. No.: HY-N4185
CAS No.: 61153-77-3
Licoflavone A is an orally active PTP1B/VEGFR-2 inhibitor, with an IC50 of 54.5 μM against PTP1B, an IC50 of 14.36 μM and a Kd of 142.38 nM against human VEGFR-2. Licoflavone A blocks the PI3K/AKT and MEK/ERK signaling pathways. Licoflavone A induces G1 phase cell cycle arrest, apoptosis via the intrinsic mitochondrial pathway (apoptosis), and inhibits migration, invasion and epithelial-mesenchymal transition (EMT) of gastric cancer cells. Licoflavone A inhibits the proliferation of gastric cancer cells in vitro and in xenograft models. Licoflavone A reduces the expression levels of HIF-1α, GLUT1, LDHA, PKM2 and HK2 in hypoxic gastric cancer cells, decreases glucose uptake and suppresses glycolysis. Licoflavone A can be used in research related to gastric cancer, type 2 diabetes and obesity .
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Cat. No.: HY-100462R
CAS No.: 1919853-46-5
Research Areas:  

Metabolic Disease

PTP1B-IN-2 (Standard) is the analytical standard of PTP1B-IN-2 (HY-100462). This product is intended for research and analytical applications. PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
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Cat. No.: HY-N12177
CAS No.: 1647101-05-0
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC50 of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .
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