2 Results for "

Ruminococcaceae

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Ruminococcaceae" in MCE Product Catalog:

Xanthan gum
Xanthan gum
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Cat. No.: HY-A0103
CAS No.: 11138-66-2
Xanthan gum interacts with gelatin (HY-Y1365) via hydrogen bonds, thereby increasing the viscosity and stability of the hydrogel while promoting cell growth and creating a microenvironment conducive to cell differentiation [1][2]. Xanthan gum induces pro-inflammatory responses by increasing the levels of TNF-α, IL-6, and IL-10. Xanthan gum can be used for inflammation and immunology research .
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Castalagin
Castalagin
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Cat. No.: HY-N20707
CAS No.: 24312-00-3
Category:  

Acalypha australis L. Phenols Polyphenols Plants Fagaceae

Target:  

PARP Topoisomerase Penicillin-binding protein (PBP) PD-1/PD-L1 Bacterial Parasite

Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections .
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