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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
SRC-1
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "SRC-1" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: dTAG-13
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FKBP12 PROTAC dTAG-13 (dTAG-13) is a FKBP12 F36V PROTAC degrader and a PXR partial agonist. FKBP12 PROTAC dTAG-13 induces ubiquitination and proteasomal degradation of proteins tagged with FKBP12 F36V, without degrading wild-type FKBP12 or un-fused PXR. It weakly promotes the recruitment of SRC-1, strongly inhibits the interaction between NCoR and PXR, and upregulates the expression of CYP3A4 and other drug metabolism-related genes. FKBP12 PROTAC dTAG-13 is applicable to research related to breast cancer and leukemia [1] .
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eCF506 (NXP900) is a highly potent and orally active YES1/SRC kinase inhibitor with an IC50 of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer [1].
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2 Cited Publications
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GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation [1].
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Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC50 of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research [1] .
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PDS-0330 is a specific and potent Claudin-1 inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis [1].
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1 Cited Publications
Cat. No.: HY-P701321
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SRC; Tyrosine Kinase Pp60c-SRC; Prev. SRC1; P60-SRC; C-SRC; Protooncogene SRC, Rous Sarcoma; ASV; Tyrosine-Protein Kinase SRC-1; V-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog; Pp60c-SRC; Proto-Oncogene Tyrosine-Protein Kinase SRC; THC6;
Cat. No.: HY-P5464
CAS No.: 227929-80-8
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Cat. No.: HY-P5464A
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TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM [1].
Cat. No.: HY-P5458
CAS No.: 394658-24-3
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Cat. No.: HY-RS13749
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SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09089
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NCOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for NCOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P3773
CAS No.: 168781-78-0
Cat. No.: HY-175264
CAS No.: 2530027-77-9
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MI891 is a highly selective PXR antagonist (IC50 = 3.76 μM, Kd = 1.7 μM) and inverse agonist (IC50 = 6.1 μM). MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272)-induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases [1].
Cat. No.: HY-112096S
Synonyms: NXP900-d5
Cat. No.: HY-P5559
CAS No.: 2582803-80-1
Cat. No.: HY-139562
CAS No.: 2314378-09-9
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BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
