2530027-77-9
2530027-77-9
Chemical Structure
MI891
- CAS No.: 2530027-77-9
- Formula:C23H14Cl2F2N6O
- Molecular Weight:499.30
SMILES: O=C(N)C1=CC(CN2N=NC(C3=C(C4=CC=C(Cl)C=C4)N=C5C(F)=CC(F)=CN53)=C2)=CC=C1Cl
Biological Activity: MI891 is a highly selective PXR antagonist (IC50 = 3.76 μM, Kd = 1.7 μM) and inverse agonist (IC50 = 6.1 μM). MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272)-induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MI891 | 99.90% | MI891 is a highly selective PXR antagonist (IC50 = 3.76 μM, Kd = 1.7 μM) and inverse agonist (IC50 = 6.1 μM). MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272)-induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases. | ||||||||||||||||||||
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References
Keywords
