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Cat. No.: HY-P5559

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ND1-YL2

ND1-YL2 is a PROTAC that selectively degrades SRC-1 via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2582803-80-1
Formula: C₁₁₄H₁₈₉N₂₇O₂₈
Molecular Weight:2385.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ND1-YL2 Chemical Structure

CAS No.: 2582803-80-1

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Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

SRC-1^[1].

All PROTACs Isoforms :

Chemical Information

CAS No. 2582803-80-1
Molecular Weight 2385.88
Formula C₁₁₄H₁₈₉N₂₇O₂₈
Sequence

Arg-Leu-Ala-Ala-Ala-Ala-Leu-Leu-Pro-Pro-Thr-Glu-Gln-Asp-Leu-{S-2(4-Pentenyl)Ala}-Lys-Leu-{(Cyclohexyl)Ala}-{S-2(4-Pentenyl)Ala}-Tyr-NH2
Sequence Shortening

RLAAAALLPPTEQDL-{S-2(4-Pentenyl)Ala}-KL-{(Cyclohexyl)Ala}-{S-2(4-Pentenyl)Ala}-Y-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee Y, et al. Targeted Degradation of Transcription Coactivator SRC-1 through the N-Degron Pathway. Angew Chem Int Ed Engl. 2020 Sep 28;59(40):17548-17555. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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