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Results for "

TP53

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (21) Autophagy (7) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (1) CDK (2) Deubiquitinase (2) DNA/RNA Synthesis (2) Drug Derivative (1) E1/E2/E3 Enzyme (4) Environmental Pollutants (1) Ferroptosis (5) Insecticide (2) Interleukin Related (1) Ligands for E3 Ligase (1) MDM-2/p53 (22) MHC (1) Molecular Glues (1) mRNA (1) mTOR (1) NF-κB (1) Parasite (2) Photosensitizer (3) PI3K (2) Polo-like Kinase (PLK) (2) Reactive Oxygen Species (ROS) (4) Reference Standards (4) Small Interfering RNA (siRNA) (14) Wee1 (1) β-catenin (1)
By Research Areas:	Cancer (41) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (10) Antisense Oligonucleotides (1) siRNAs (14)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19980

Eprenetapopt 10+ Cited Publications APR-246; PRIMA-1Met	MDM-2/p53 Autophagy Apoptosis Ferroptosis	Cancer
Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

HY-10029

Nutlin-3a Maximum Cited Publications 66 Publications Verification Rebemadlin	MDM-2/p53 E1/E2/E3 Enzyme Autophagy Apoptosis	Cancer
Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC₅₀=90 nM). Nutlin-3a inhibits *MDM2-p53* interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .

HY-156633

Rezatapopt 3 Publications Verification PC14586	MDM-2/p53	Cancer
Rezatapopt (PC14586) is an orally active antineoplastic agent. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure. Rezatapopt demonstrates tumor inhibition and regression in mouse models with established human tumor xenografts harboring the TP53 Y220C mutation .

HY-P10925

Zolucatetide FOG-001; I-66	β-catenin	Cancer
Zolucatetide (FOG-001;I-66) is a potent β-catenin inhibitor with an IC₅₀ of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species (ROS) Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

HY-19980A

PRIMA-1 2 Publications Verification NSC-281668	Autophagy MDM-2/p53 Ferroptosis Apoptosis	Cancer
PRIMA-1 (NSC-281668) is a mutant *p53* reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.

HY-176083

ASTX295	MDM-2/p53 Caspase Apoptosis	Cancer
ASTX295 is an orally active and selective MDM2 antagonist with an IC₅₀ of <1 nM. ASTX295 inhibits the *MDM2-p53* interaction, activates wild-type *TP53, and thereby induces the expression of relevant transcriptional targets, leading to cell death. ASTX295 drives the transition of pancreatic cancer cells from senescence to apoptosis* and regulates *p53* and DNA damage biomarkers. ASTX295 can be used for the research of hematologic malignancies and pancreatic cancer .

HY-P4210

Sulanemadlin 1 Publications Verification ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-15898

Y-320 5 Publications Verification	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC₅₀ values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .

HY-16271

Kevetrin hydrochloride 4 Publications Verification 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride	MDM-2/p53 Apoptosis	Cancer
Kevetrin hydrochloride is a potent activator of *p53, induces apoptosis in TP53* wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells .

HY-D0892

NSP-DMAE-NHS	Biochemical Assay Reagents	Cancer
NSP-DMAE-NHS is an acridinium ester-based signal amplifier that can act as a luminescent probe to effectively improve the detection performance of biosensors. NSP-DMAE-NHS preserves the biochemical activity of biomolecules during the conjugation process. NSP-DMAE-NHS has been successfully applied to label mouse anti-human PI3 monoclonal antibodies for chemiluminescent immunoassays, as well as for pre-competitive chemiluminescent immunochromatographic detection of *TP53* fusion proteins. NSP-DMAE-NHS can be used in detection studies of cancer and related biomarkers .

HY-17493

MI-773 5+ Cited Publications	MDM-2/p53 Apoptosis	Neurological Disease Cancer
MI-773 is an orally active, selective MDM2-p53 interaction inhibitor with a K_i of 0.88 nM for MDM2. MI-773 blocks the *MDM2*-TP53 interaction. MI-773 potently activates *p53. MI-773 induces Apoptosis*. MI-773 causes tumor regression in xenograft models of adenoid cystic carcinoma. MI-773 exhibits anticancer effects in neuroblastoma. MI-773 TFA can be used for the research of adenoid cystic carcinoma .

HY-148409

MMRi62	Ferroptosis Apoptosis Autophagy MDM-2/p53	Cancer
MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 .

HY-A0169A

Methyl aminolevulinate hydrochloride 1 Publications Verification	Reactive Oxygen Species (ROS) Photosensitizer	Cancer
Methyl aminolevulinate hydrochloride is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate hydrochloride penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate hydrochloride acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate hydrochloride reduces the expression of the proliferation marker K_i-67 and the early skin carcinogenesis marker *TP53*. Methyl aminolevulinate hydrochloride delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate hydrochloride is applicable to research related to actinic keratosis and basal cell carcinoma .

HY-171499

Cenersen EL625	MDM-2/p53	Cancer
Cenersen (EL625) is an oligonucleotide targeting *TP53. Cenersen can eliminate the activity of TP53* gain-of-function mutants and increase the sensitivity of lymphoma cells to cytotoxic chemotherapy in vitro. Cenersen can be used for the study of chronic lymphocytic leukemia (CLL) .

HY-158039

YCH2823	Deubiquitinase Apoptosis	Cancer
YCH2823 is an inhibitor of USP7 (IC₅₀ = 49.6 nM; K_d = 0.117 μM). YCH2823 shows significant efficacy in inhibiting TP53 wild-type and mutant tumors, with approximately 5-fold higher potency than FT671. YCH2823 induce apoptosis. YCH2823 synergistic effects with mTOR inhibitors .

HY-W181530

NCT02	Molecular Glues CDK Apoptosis Ligands for E3 Ligase	Cancer
NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying *TP53* defects or belonging to the consensus molecular subtype CMS4. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models .

HY-RS14912

TP53 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53 Human Pre-designed siRNA Set A TP53 Human Pre-designed siRNA Set A

HY-114231

Exaluren 2 Publications Verification ELX-02; NB-124	Drug Derivative	Inflammation/Immunology
Exaluren (ELX-02; NB-124) is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations .

HY-P11089

TP53 neoepitope	MHC	Cancer
TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8 ⁺ T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) .

HY-107835

Flumethrin FCR 2769	Environmental Pollutants Apoptosis Bcl-2 Family Parasite Insecticide	Infection Cancer
Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide . Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer .

HY-124036

DS-7423	PI3K mTOR	Cancer
DS-7423 is a dual PI3K and mTOR inhibitor, with IC₅₀ values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity .

HY-100765

BI-0252	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
BI-0252 is an orally active, selective *MDM2-p53* inhibitor with an IC₅₀ of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis .

HY-174511

*Human TP53* mRNA**	mRNA	Cancer
Human TP53 mRNA encodes the human tumor protein p53 (TP53) protein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. TP53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.

HY-N1022

11-Hydroxytephrosin	NF-κB	Inflammation/Immunology Cancer
11-Hydroxytephrosin is a potent NF-κB inhibitor with an IC₅₀ of 0.19 μM or 4.21 μM. 11-Hydroxytephrosin is isolated from A. fruticosa. 11-Hydroxytephrosin inhibits the activation of NF-κB. 11-Hydroxytephrosin can be used in research related to cervical cancer and inflammatory diseases .

HY-RS14913

Tp53 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tp53 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tp53 Rat Pre-designed siRNA Set A Tp53 Rat Pre-designed siRNA Set A

HY-10029A

(Rac)-Nutlin-3 (Rac)-Rebemadlin	MDM-2/p53 Autophagy Apoptosis E1/E2/E3 Enzyme	Cancer
(Rac)-Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC₅₀=90 nM). (Rac)-Nutlin-3 inhibits *MDM2-p53* interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. (Rac)-Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas .

HY-175000

L14-8	Ferroptosis Polo-like Kinase (PLK) MDM-2/p53	Endocrinology Cancer
L14-8 is a potent ferroptosis inducer. L14-8 promotes PLK1 degradation via ubiquitination, increasing TP53 phosphorylation to enhance SAT1 transcription, thereby triggering ferroptosis and cancer cell death. L14-8 can be used for the study of advanced prostate cancer .

HY-178224

Morindone	Apoptosis DNA/RNA Synthesis	Cancer
Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer .

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	MDM-2/p53 Apoptosis Autophagy Ferroptosis	Cancer
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

HY-179560

PMV6-PEG4-BI2536	Polo-like Kinase (PLK) MDM-2/p53	Cancer
PMV6-PEG4-BI2536 is a *p53-Y220C-PLK1* dual-functional compound, composed of a high-affinity *p53-Y220C* mutant binder (K_d ≈ 2.5 nM) and a potent PLK1 kinase inhibitor (IC₅₀ = 0.83 nM). PMV6-PEG4-BI2536 triggers TP53 ^Y220C cell G2/M arrest and apoptosis through PLK1 mislocalization and kinase inhibition, independent of p53 transcriptional reactivation. PMV6-PEG4-BI2536 can be used for the study of TP53 mutant cancers .

HY-W013053R

Dibenz[a,h]anthracene (Standard) DBA (Standard); 1,2,5,6-Dibenzanthracene (Standard); Benzo[k]tetraphene (Standard)	DNA/RNA Synthesis Apoptosis Reference Standards MDM-2/p53	Cancer
Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .

HY-164544

USP7-055	Deubiquitinase	Cancer
USP7-055 is a USP7 inhibitor. USP7-055 can be used in cancer research .

HY-RS14922

TP53RK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53RK Human Pre-designed siRNA Set A contains three designed siRNAs for TP53RK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53RK Human Pre-designed siRNA Set A TP53RK Human Pre-designed siRNA Set A

HY-RS14915

TP53BP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53BP1 Human Pre-designed siRNA Set A TP53BP1 Human Pre-designed siRNA Set A

HY-RS14916

TP53BP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53BP2 Human Pre-designed siRNA Set A TP53BP2 Human Pre-designed siRNA Set A

HY-RS14920

TP53INP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53INP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53INP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53INP1 Human Pre-designed siRNA Set A TP53INP1 Human Pre-designed siRNA Set A

HY-RS14917

TP53I11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53I11 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53I11 Human Pre-designed siRNA Set A TP53I11 Human Pre-designed siRNA Set A

HY-RS26028

Tp53i3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tp53i3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53i3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tp53i3 Rat Pre-designed siRNA Set A Tp53i3 Rat Pre-designed siRNA Set A

HY-RS14918

TP53I13 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53I13 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53I13 Human Pre-designed siRNA Set A TP53I13 Human Pre-designed siRNA Set A

HY-RS14919

TP53I3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53I3 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53I3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53I3 Human Pre-designed siRNA Set A TP53I3 Human Pre-designed siRNA Set A

HY-RS14921

TP53INP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53INP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53INP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53INP2 Human Pre-designed siRNA Set A TP53INP2 Human Pre-designed siRNA Set A

HY-RS14914

TP53AIP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TP53AIP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53AIP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TP53AIP1 Human Pre-designed siRNA Set A TP53AIP1 Human Pre-designed siRNA Set A

HY-150620

BI-0282	MDM-2/p53	Cancer
BI-0282 (Compound 1) is a potent *MDM2-p53* interaction inhibitor .

HY-107835R

Flumethrin (Standard) FCR 2769 (Standard)	Reference Standards Insecticide Parasite Apoptosis Bcl-2 Family	Infection Cancer
Flumethrin (Standard) (FCR 2769 (Standard)) is the analytical standard of Flumethrin (HY-107835). This product is intended for research and analytical applications. Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer.

HY-A0169

Methyl aminolevulinate	Reactive Oxygen Species (ROS) Photosensitizer	Cancer
Methyl aminolevulinate is a sensitizer used in photodynamic therapy (PDT). Methyl aminolevulinate penetrates the skin and induces the production of photoactive porphyrins including protoporphyrin IX in cells; upon exposure to appropriate light, it generates ROS, which triggers cellular oxidation and cell death. Methyl aminolevulinate acts as a photo-damage reversing agent through epidermal reconstruction, cytokine-mediated activation of dermal fibroblasts, elastin breakdown, new collagen formation, and compression of dilated capillaries. Methyl aminolevulinate reduces the expression of the proliferation marker K_i-67 and the early skin carcinogenesis marker *TP53*. Methyl aminolevulinate delays the onset of ultraviolet-induced skin tumors and reduces tumor burden in hairless mice. Methyl aminolevulinate is applicable to research related to actinic keratosis and basal cell carcinoma .

HY-180331

NVP-CFC218	MDM-2/p53	Cancer
NVP-CFC218 is a selective *TP53-MDM2* inhibitor with a structure and biochemical profile similar to NVP-CGM097 (HY-15954) (IC₅₀ of 1.6 nM: displacing the p53 peptide from the surface of HDM2). It is used to analyze pharmacological sensitivity in cell lines and is also applicable in cancer research ^[1] .

HY-186013

CML-07-119	Apoptosis	Cancer
CML-07-119 is a selective inhibitor of GGPP synthase (GGPPS) with an IC₅₀ of ~27 nM. CML-07-119 induces apoptosis and exhibits anticancer activity against acute myeloid leukemia (AML) cells, including those harbouring TP53 mutations. CML-07-119 inhibits tumor growth in an AML mouse xenograft model. CML-07-119 can be used for AML research .

HY-164828

Rezatapopt analog-1 PC14586 analog-1	MDM-2/p53	Cancer
Rezatapopt analog-1 (PC14586 analog-1) (1919) is a Rezatapopt (HY-156633) analog. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure .

HY-RS28596

Tp53inp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tp53inp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp53inp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tp53inp1 Rat Pre-designed siRNA Set A Tp53inp1 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-19980G

Eprenetapopt

APR-246; PRIMA-1Met

Fluorescent Dye

Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

Cat. No.	Product Name	Type

HY-19980G

Eprenetapopt

APR-246; PRIMA-1Met

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P10925

Zolucatetide FOG-001; I-66	β-catenin	Cancer
Zolucatetide (FOG-001;I-66) is a potent β-catenin inhibitor with an IC₅₀ of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species (ROS) Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

HY-P4210

Sulanemadlin 1 Publications Verification ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-P11089

TP53 neoepitope	MHC	Cancer
TP53 neoepitope is a high-affinity antigenic peptide targeting HLA-A. TP53 neoepitope can triggers CD8 ⁺ T cell-mediated killing of TP53-mutant tumor cells. TP53 neoepitope is promising for research of solid tumors harboring TP53 hotspot mutations (e.g., R175H, R273H) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-178224

Morindone	Quinones Structural Classification Morinda citrifolia Linn. Rubiaceae Benzene Quinones Plants Source Classification	Apoptosis DNA/RNA Synthesis
Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer .

Species:	Human (11) Rhesus Macaque (1) Rat (1)
Tag:	SUMO (1) His (11) Tag Free (1) Avi (6) TAT (1)
Source:	HEK293 (6) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71703

	p53 Protein, Rat (His) TP53; P53; Cellular tumor antigen p53; Tumor suppressor p53	Rat	E. coli
	The p53 protein acts as a tumor suppressor, regulates the cell cycle and induces growth arrest or apoptosis.It activates genes that inhibit cell division and trigger apoptosis by controlling the expression of various proteins.p53 Protein, Rat (His) is the recombinant rat-derived p53 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P74657

	p53 Protein, Rhesus Macaque Cellular tumor antigen p53; TP53; Antigen NY-CO-13	Rhesus Macaque	E. coli
	p53 protein, a tumor suppressor, induces growth arrest or apoptosis in various tumors, regulating cell division through gene control, including cyclin-dependent kinase inhibitors. It stimulates BAX and FAS antigen expression or represses Bcl-2 to induce apoptosis. p53's multifaceted role underscores its importance in orchestrating cellular responses, maintaining genomic integrity, and countering aberrant cell proliferation. p53 Protein, Rhesus Macaque is the recombinant Rhesus Macaque-derived p53 protein, expressed by E. coli , with tag free.

HY-P705518

	*Cellular tumor antigen P53/TP53* Protein, Human (His)** Cellular tumor antigen p53; p53; TP53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	Human	E. coli

HY-P77778

	*HLA-A02:01&B2M&P53 WT(HMTEVVRRC) Monomer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77780

	*HLA-A02:01-B2M&P53 WT(HMTEVVRRC) Tetramer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77779

	*HLA-A02:01&B2M&P53 WT(HMTEVVRRC) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77775

	*HLA-A02:01&B2M&P53 R175H(HMTEVVRHC) Monomer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77777

	*HLA-A02:01&B2M&P53 R175H(HMTEVVRHC) Tetramer Protein, Human (HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P77776

	*HLA-A02:01&B2M&P53 R175H(HMTEVVRHC) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53	Human	HEK293

HY-P71919

	TIGAR Protein, Human (TAT) 6-bisphosphatase TIGAR; C12ORF5; chromosome 12 open reading frame 5; FR2BP; Fructose-2,6-bisphosphatase TIGAR; Fructose-2,6-bisphosphate 2-phosphatase; Probable fructose 2,6 bisphosphatase TIGAR; Probable fructose-2; tigar; TIGAR_HUMAN; TP53 induced glycolysis and apoptosis regulator; TP53 induced glycolysis regulatory phosphatase; TP53-induced glycolysis and apoptosis regulator; Transactivated by NS3TP2 protein	Human	E. coli
	TIGAR is a protein that helps cells survive stress by regulating glycolysis and promoting cell survival. It reduces reactive oxygen species (ROS) levels and protects against oxidative damage. TIGAR also plays a role in promoting tissue regeneration and has neuroprotective effects. In cancer cells, TIGAR promotes DNA repair and is involved in tumor progression. TIGAR Protein, Human (TAT) is the recombinant human-derived TIGAR protein, expressed by E. coli , with C-TAT labeled tag.

HY-P72257

	*Cellular tumor antigen P53/TP53, Human (His-SUMO)* 1 Publications Verification BCC7; p53; p53 tumor suppressor; Phosphoprotein p5	Human	E. coli
	The cellular tumor antigen P53/TP53 is a tumor suppressor that can induce growth arrest or apoptosis in a variety of tumor types. It regulates the cell cycle by negatively controlling genes critical for division. Cellular tumor antigen P53/TP53, Human (His-SUMO) is the recombinant human-derived Cellular tumor antigen P53/TP53, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P74632

	PIG3 Protein, Human (His) Quinone oxidoreductase PIG3; TP53I3; PIG3	Human	E. coli
	PIG3 is a key player in cellular processes, functioning as an enzyme that catalyzes NADPH-dependent quinone reduction. It exhibits moderate enzymatic activity towards β-naphthoquinone, with the para -quinone isomer (1,2-β-naphthoquinone) compared to the para -isomer (1,4-β-naphthoquinone). Obvious preference. PIG3 Protein, Human (His) is the recombinant human-derived PIG3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70417

	GAMT Protein, Human (His) rHuGuanidinoacetate N-methyltransferase/GAMT, His; Guanidinoacetate N-methyltransferase; GAMT; PIG2; TP53I2	Human	E. coli
	GAMT protein uses S-adenosylmethionine as a methyl donor to catalyze the conversion of guanidinoacetic acid into creatine, playing a key role in cell metabolism. This enzyme activity is essential for the biosynthesis of creatine, a compound necessary for cellular energy storage and transport. GAMT Protein, Human (His) is the recombinant human-derived GAMT protein, expressed by E. coli , with N-6His, C-6His labeled tag.

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Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (14) Rabbit (22)
Reactivity:	Human (36) mouse (1) rat (1) Rat (8) Mouse (11) Monkey (1)
Application:	WB FC ICC/IF (1) IHC-P (21) ICC/IF (12) IP (6) WB (27) FC (6) ELISA (9)
Isotype:	IgG (21) IgG1 (14) IgG/Kappa (1)
Conjugation:	Non-conjugated (36) Biotin (2)
Clonality:	Polyclonal (2) Monoclonal (17) Monoclonal Antibody (2) Recombinant (9)
Modification:	Phosphorylated (3) Acetylated (2) Unmodified (16)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80938

	p53 Antibody 2 Publications Verification TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
	p53 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to p53.

HY-P83948

	p53 Antibody (YA3645) LFS1, TRP53, TP53	WB, IHC-P, ELISA	Human
	p53 Antibody (YA3645) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p53.

HY-P80843

	Phospho-p53 (Ser37) Antibody 1 Publications Verification TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF	Human, Mouse, Rat
	Phospho-p53 (Ser37) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-p53 (Ser37).

HY-P83948A

	p53 Antibody (YA3645)(PBS only) LFS1, TRP53, TP53	WB, IHC-P, ELISA	Human
	p53 Antibody (YA3645) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p53.

HY-P86652

	Phospho-p53(S15) Antibody (YA6344) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF	Human
	Phospho-p53(S15) Antibody (YA6344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53(S15).

HY-P80844

	Phospho-p53 (Ser6) Antibody (YA166) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC-P, IP	Human
	Phospho-p53 (Ser6) Antibody (YA166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53 (Ser6).

HY-P810652

	Phospho-p53 (Ser376) Antibody (YA9912) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB	Human, Mouse
	Phospho-p53 (Ser376) Antibody (YA9912) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-p53 (Ser376).

HY-P810653

	Phospho-p53 (Ser33) Antibody (YA9913) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Phospho-p53 (Ser33) Antibody (YA9913) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-p53 (Ser33).

HY-P810656

	Phospho-p53 (Ser20) Antibody (YA9916) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB	Human
	Phospho-p53 (Ser20) Antibody (YA9916) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-p53 (Ser20).

HY-P810654

	Phospho-p53 (Thr55) Antibody (YA9914) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC-P	Human
	Phospho-p53 (Thr55) Antibody (YA9914) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-p53 (Thr55).

HY-P810655

	Acetyl-p53 (Lys382) Antibody (YA9915) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, ICC/IF	Human, Mouse
	Acetyl-p53 (Lys382) Antibody (YA9915) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Acetyl-p53 (Lys382).

HY-P80844A

	Phospho-p53 (Ser6) Antibody (YA166)(PBS only) TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53	WB, IHC-P, IP	Human
	Phospho-p53 (Ser6) Antibody (YA166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53 (Ser6).

HY-P86169

	p53 Antibody (YA5861) Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; TP53; Transformation related protein 53; TRP53; tumor antigen p55; Tumor protein 53; Tumor protein p53; Tumor suppressor p53;	WB, IHC-P, ICC/IF, IP, ELISA	Human
	p53 Antibody (YA5861) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53.

HY-P82831

	TP53BP2 Antibody (YA2576) 53BP2; ASPP2; p53BP2; PPP1R13A; TP53bp2	WB, IHC-P, ICC/IF	Human
	TP53BP2 Antibody (YA2576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.

HY-P88214

	TP53I3 (PIG3) Antibody (YA7898) PIG3	IHC-P	Human
	TP53I3 (PIG3) Antibody (YA7898) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53I3 (PIG3).

HY-P88214A

	TP53I3 (PIG3) Antibody (YA7898)(PBS only) PIG3	IHC-P	Human
	TP53I3 (PIG3) Antibody (YA7898) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53I3 (PIG3).

HY-P84041

	SAA1 Antibody (YA3738) SAA; PIG4; SAA2; TP53I4	IHC-P, FC, ELISA	Human
	SAA1 Antibody (YA3738) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SAA1.

HY-P84041A

	SAA1 Antibody (YA3738)(PBS only) SAA; PIG4; SAA2; TP53I4	IHC-P, FC, ELISA	Human
	SAA1 Antibody (YA3738) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SAA1.

HY-P80257

	p53 Antibody (YA250) 1 Publications Verification	WB, ICC/IF	Human
	p53 Antibody (YA250) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53.

HY-P80260

	p53 (acetyl K370)Antibody (YA248) 1 Publications Verification	WB, ICC/IF, IP	Human
	p53 (acetyl K370)Antibody (YA248) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53 (acetyl K370).

HY-P80472

	Phospho-p53 (Ser392) Antibody (YA167) 1 Publications Verification	WB, IHC-P, IP	Human, Mouse
	Phospho-p53 (Ser392) Antibody (YA167) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p53 (Ser392).

HY-P80258

	p53 (acetyl K382) Antibody (YA251)	WB, ICC/IF, IHC-P	Human
	p53 (acetyl K382) Antibody (YA251) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p53 (acetyl K382).

HY-P88241

	PRODH Antibody (YA7925) HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6	WB, IHC-P	Human
	PRODH Antibody (YA7925) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PRODH.

HY-P88241A

	PRODH Antibody (YA7925)(PBS only) HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6	WB, IHC-P	Human
	PRODH Antibody (YA7925) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PRODH.

HY-P88673

	TP53RK Antibody (YA8357) BUD32; C20orf64; dJ101A2; Nori-2; Nori-2p; PRPK	IHC-P	Human, Mouse, Rat
	TP53RK Antibody (YA8357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53RK.

HY-P84796

	p63 Antibody (YA4493) TP63,AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)	IHC-P, FC, ELISA	Human
	p63 Antibody (YA4493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P84796A

	p63 Antibody (YA4493)(PBS only) TP63,AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)	IHC-P, FC, ELISA	Human
	p63 Antibody (YA4493) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P88673A

	TP53RK Antibody (YA8357)(PBS only) BUD32; C20orf64; dJ101A2; Nori-2; Nori-2p; PRPK	IHC-P	Human, Mouse, Rat
	TP53RK Antibody (YA8357) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TP53RK.

HY-P82704

	MAD1L1 Antibody (YA2449) hMAD1; HsMAD1; MAD1; MAD1L1; PIG9; TP53I9; TXBP181	WB	Human, Mouse, Rat
	MAD1L1 Antibody (YA2449) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAD1L1.

HY-P86277

	TP53BP2 Antibod (YA5969) TP53BP2; ASPP2; BBP; Apoptosis-stimulating of p53 protein 2 ; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2;	WB, IHC-P, ICC/IF	Human
	TP53BP2 Antibody (YA5969) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.

HY-P81996

	Prostaglandin E Synthase Antibody (YA1741) PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prostaglandin E Synthase.

HY-P81996A

	Prostaglandin E Synthase Antibody (YA1741)(PBS only) PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prostaglandin E Synthase.

HY-P86435

	53BP1 Antibody (YA6127) TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1	WB, ICC/IF, IP, ELISA	Human
	53BP1 Antibody (YA6127) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 53BP1.

HY-P86745

	p63 Antibody (YA6437) P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;	WB, FC	Human
	p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P86745A

	p63 Antibody (YA6437)(PBS only) P63_HUMAN; Tumor protein 63; TP63; Chronic ulcerative stomatitis protein(CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63(TP63); Tumor protein p73-like(p73L); p40; p51; KET; P63; P73H; P73L; TP73L; AIS; LMS; NBP; RHS; p40; p51; EEC3; OFC8; SHFM4; TP53L; p53CP; TP53CP; B(p51A); B(p51B); P51A; TAp63gamma; P51B; TAp63alpha; P51delta; TAp63delta; P51delNalpha; deltaNp63 alpha; P51delNbeta; deltaNp63 beta; P51delNgamma; deltaNp63gamma; p40-deltaNp63; p40-deltaNp63;	WB, FC	Human
	p63 Antibody (YA6437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p63.

HY-P810476

	MAD1L1 Antibody (YA9774) MAD1L1, Mitotic Arrest Deficient 1 Like 1, TXBP181, MAD1, HsMAD1, TP53I9, PIG9, Mitotic Spindle Assembly Checkpoint Protein MAD1, Mitotic Arrest Deficient 1-Like Protein 1, Mitotic Checkpoint MAD1 Protein Homolog, MAD1 Mitotic Arrest Deficient Like 1, Tax-Binding Protein 181, MAD1-Like Protein 1, MAD1 (Mitotic Arrest Deficient, Yeast, Homolog)-Like 1, Mitotic-Arrest Deficient 1, Yeast, Homolog-Like 1, MAD1 Mitotic Arrest Deficient-Like 1 (Yeast), Tumor Protein P53 Inducible Protein 9, HMAD1, MVA7	WB FC ICC/IF	Human, mouse, rat
	MAD1L1 Antibody (YA9774) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to MAD1L1.

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19980G

Eprenetapopt APR-246; PRIMA-1Met	MDM-2/p53 Apoptosis Autophagy Ferroptosis	Cancer
Eprenetapopt (GMP) (APR-246(GMP)) is Eprenetapopt (HY-19980) in GMP grade. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .

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