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Terminalia chebula

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By Targets:	Bacterial (1) COX (2) Fungal (1) Glycosidase (1) Influenza Virus (2) Keap1-Nrf2 (2) Lipoxygenase (2) NF-κB (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) SARS-CoV (2)
By Research Areas:	Cancer (1) Infection (4) Inflammation/Immunology (3) Metabolic Disease (2)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1996

Chebulagic acid 5 Publications Verification	COX Lipoxygenase SARS-CoV Influenza Virus	Infection Inflammation/Immunology
Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀ of 9.76 μM.

HY-N4170

Chebulic acid 2 Publications Verification	Keap1-Nrf2 Reactive Oxygen Species (ROS)	Metabolic Disease
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

HY-N12500

1'-O-Methyl neochebulinate	Glycosidase	Others
1'-O-Methyl neochebulinate, hydrolyzable tannin, is an α-glucosidase inhibitor with IC₅₀ value of 59.5 μM, isolated from the fruits of Terminalia chebula Retz .

HY-N1996R

Chebulagic acid (Standard)	Reference Standards COX Lipoxygenase SARS-CoV Influenza Virus	Infection Inflammation/Immunology
Chebulagic acid (Standard) is the analytical standard of Chebulagic acid. This product is intended for research and analytical applications. Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀ of 9.76 μM.

HY-N18656

Terminalia chebula extract	Bacterial	Infection
Terminalia chebula extract, derived from the fruit of the Terminalia chebula tree. Rich in bioactive compounds such as tannins, flavonoids, phenols, and organic acids like gallic acid and ellagic acid, this extract demonstrates a wide range of pharmacological activities. It acts as a natural laxative, supports digestive health, and exhibits potent antioxidant, anti-inflammatory, and antibacterial properties, effectively targeting various pathogenic bacteria, including Helicobacter pylori, Staphylococcus aureus, and Escherichia coli. Terminalia Chebula Extract also shows significant hepatoprotective effects, shielding the liver from damage through antioxidant and anti-inflammatory mechanisms. It has nephroprotective properties, alleviating renal dysfunction and enhancing kidney health by modulating inflammatory pathways. Additionally, the extract demonstrates neuroprotective activity, reducing neuronal damage and improving memory function. It has potential anti-diabetic effects, enhancing glucose uptake and reducing oxidative stress.

HY-114335

Triphala	NF-κB Fungal	Infection Inflammation/Immunology Cancer
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica . Triphala inhibits NF-κB activation. Triphala exerts antifungal action . Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.

HY-N4170R

Chebulic acid (Standard)	Reference Standards Keap1-Nrf2 Reactive Oxygen Species (ROS)	Metabolic Disease
Chebulic acid (Standard) is the analytical standard of Chebulic acid (HY-N4170). This product is intended for research and analytical applications. Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

Chebulagic acid 5 Publications Verification	Classification of Application Fields Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Inflammation/Immunology Disease Research Fields Source Classification	COX Lipoxygenase SARS-CoV Influenza Virus
Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀ of 9.76 μM.

Chebulic acid 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Combretaceae Phenols Polyphenols Metabolic Disease Terminalia chebula Retz. Plants Disease Research Fields Source Classification	Keap1-Nrf2 Reactive Oxygen Species (ROS)
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

1'-O-Methyl neochebulinate	Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Source Classification	Glycosidase
1'-O-Methyl neochebulinate, hydrolyzable tannin, is an α-glucosidase inhibitor with IC₅₀ value of 59.5 μM, isolated from the fruits of Terminalia chebula Retz .

Chebulagic acid (Standard)	Structural Classification Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Source Classification	Reference Standards COX Lipoxygenase SARS-CoV Influenza Virus
Chebulagic acid (Standard) is the analytical standard of Chebulagic acid. This product is intended for research and analytical applications. Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀ of 9.76 μM.

Terminalia chebula extract	Structural Classification Extract	Bacterial
Terminalia chebula extract, derived from the fruit of the Terminalia chebula tree. Rich in bioactive compounds such as tannins, flavonoids, phenols, and organic acids like gallic acid and ellagic acid, this extract demonstrates a wide range of pharmacological activities. It acts as a natural laxative, supports digestive health, and exhibits potent antioxidant, anti-inflammatory, and antibacterial properties, effectively targeting various pathogenic bacteria, including Helicobacter pylori, Staphylococcus aureus, and Escherichia coli. Terminalia Chebula Extract also shows significant hepatoprotective effects, shielding the liver from damage through antioxidant and anti-inflammatory mechanisms. It has nephroprotective properties, alleviating renal dysfunction and enhancing kidney health by modulating inflammatory pathways. Additionally, the extract demonstrates neuroprotective activity, reducing neuronal damage and improving memory function. It has potential anti-diabetic effects, enhancing glucose uptake and reducing oxidative stress.

Triphala	Infection Natural Products Classification of Application Fields Combretaceae Terminalia chebula Retz. Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Fungal
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica . Triphala inhibits NF-κB activation. Triphala exerts antifungal action . Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.

Chebulic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Source Classification	Reference Standards Keap1-Nrf2 Reactive Oxygen Species (ROS)
Chebulic acid (Standard) is the analytical standard of Chebulic acid (HY-N4170). This product is intended for research and analytical applications. Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Terminalia chebula

Inhibitors & Agonists

NaturalProducts

Natural
Products