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U2AF1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) DNA/RNA Synthesis (4) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153736

NSC 194308	DNA/RNA Synthesis	Cancer
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .

HY-178155

AP232	DNA/RNA Synthesis Autophagy	Cancer
AP232 is a selective *U2AF1-UHM* Inhibitor with an IC₅₀ of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia .

HY-RS15313

U2AF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2AF1 Human Pre-designed siRNA Set A U2AF1 Human Pre-designed siRNA Set A

HY-RS18687

U2af1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Mouse Pre-designed siRNA Set A U2af1 Mouse Pre-designed siRNA Set A

HY-178155A

AP232 dihydrochloride	DNA/RNA Synthesis Autophagy	Cancer
AP232 dihydrochloride is a selective *U2AF1-UHM* Inhibitor with an IC₅₀ of 7.96 μM. AP232 dihydrochloride exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 dihydrochloride exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 dihydrochloride can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 dihydrochloride can be used for the research of cancer, such as Leukemia .

HY-RS25173

U2af1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Rat Pre-designed siRNA Set A U2af1 Rat Pre-designed siRNA Set A

HY-139499

Sudemycin D6	DNA/RNA Synthesis	Cancer
Sudemycin D6 is a pre-mRNA splicing modulator with potent antitumour activity. Sudemycin D6 changes splice site usage of the DUSP11 and SRRM1 pre-mRNA. Sudemycin D6 reduces survival and alters cell cycle in haematopoietic cells expressing mutant U2AF1. Sudemycin D6 attenuates mutant U2AF1-induced haematopoietic progenitor cell expansion in U2AF1(S34F) transgenic mice. Sudemycin D6 can be used for cancer research .

Species:	Human (2)
Tag:	His (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; Transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700454

	IGFLR1 Protein, Human (HEK293, C-His) IGFLR1; IGF-like family receptor 1; TMEM149, transmembrane protein 149 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 4 , U2AF1L4; FLJ22573; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, C-His) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-6*His labeled tag.

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U2AF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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