Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
YM12617
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "YM12617" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-B0661
CAS No.: 106133-20-4
Synonyms: (R)-(-)-YM12617 free base; LY253351 free base
Category:
Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Cancer
Target:
2
Category:
Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology
Target:
Cat. No.: HY-B0661C
CAS No.: 80223-99-0
Synonyms: YM12617 hydrochloride; LY253351 hydrochloride
Target:
Research Areas:
Tamsolusin hydrochloride (YM12617 hydrochloride; LY253351 hydrochloride) is an isomer of Tamsulosin (HY-B0661). Tamsolusin hydrochloride is a sulfonamide phenethylamine derivative and a competitive antagonist of selective post-synaptic α1-adrenoceptors. Tamsolusin hydrochloride inhibits CYP3A4 activity in a non-competitive, enantiomer-specific manner, with an IC50 and Ki of 6.75 μM. Tamsolusin hydrochloride produces dose-dependent hypotension, preferentially antagonizing α1-adrenoceptor-mediated pressor responses, and inhibits α2-adrenoceptor-mediated pressor responses at high doses. Tamsolusin hydrochloride can be used in research related to various diseases such as metabolism .
Cat. No.: HY-B0661AS1
CAS No.: 2518100-55-3
Synonyms: (R)-(-)-YM12617-d4; LY253351-d4
Cat. No.: HY-B0661S
CAS No.: 1231943-97-7
Synonyms: (R)-(-)-YM12617 free base-d4; LY253351 free base-d4
Cat. No.: HY-B0661D
CAS No.: 94666-07-6
Synonyms: YM12617 free base; (Rac)-LY253351 free base
Research Areas:
(Rac)-Tamsulosin (YM12617 (free base); (Rac)-LY253351 (free base)) is an isomer of Tamsulosin (HY-B0661). (Rac)-Tamsulosin is a sulfonamide phenethylamine derivative and a competitive antagonist of selective post-synaptic α1-adrenoceptors. (Rac)-Tamsulosin inhibits CYP3A4 activity in a non-competitive, enantiomer-specific manner, with an IC50 and Ki of 6.75 μM. (Rac)-Tamsulosin produces dose-dependent hypotension, preferentially antagonizing α1-adrenoceptor-mediated pressor responses, and inhibits α2-adrenoceptor-mediated pressor responses at high doses. (Rac)-Tamsulosin can be used in research related to various diseases such as metabolism .
Cat. No.: HY-B0661AS
Synonyms: (R)-(-)-YM12617-d5; LY253351-d5
Cat. No.: HY-B0661R
CAS No.: 106133-20-4
Synonyms: (R)-(-)-YM12617 free base (Standard); LY253351 free base (Standard)
Category:
Cat. No.: HY-B0661AR
CAS No.: 106463-17-6
Synonyms: (R)-(-)-YM12617 (Standard); LY253351 (Standard)
Category:
Cat. No.: HY-B0661B
CAS No.: 106463-19-8
Synonyms: (S)-(-)-YM12617; (S)-LY253351
Target:
Research Areas:
S-Tamsulosin hydrochloride ((S)-(-)-YM12617) is a drug impurity.
Cat. No.: HY-B0661CS
CAS No.: 1189923-88-3
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
