(Rac)-Tamsulosin-d3 hydrochloride
(Rac)-Tamsulosin-d3 hydrochloride is the deuterated-labeled Tamsolusin hydrochloride (HY-B0661C). Tamsolusin hydrochloride (YM12617 hydrochloride; LY253351 hydrochloride) is an isomer of Tamsulosin (HY-B0661). Tamsolusin hydrochloride is a sulfonamide phenethylamine derivative and a competitive antagonist of selective post-synaptic α1-adrenoceptors. Tamsolusin hydrochloride inhibits CYP3A4 activity in a non-competitive, enantiomer-specific manner, with an IC50 and Ki of 6.75 μM. Tamsolusin hydrochloride produces dose-dependent hypotension, preferentially antagonizing α1-adrenoceptor-mediated pressor responses, and inhibits α2-adrenoceptor-mediated pressor responses at high doses. Tamsolusin hydrochloride can be used in research related to various diseases such as metabolism.
For research use only. We do not sell to patients.
- CAS No.: 1189923-88-3
- Formula: C20H26D3ClN2O5S
- Molecular Weight:447.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189923-88-3
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Unlabeled Cas 80223-99-0
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Molecular Weight 447.99
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Formula C20H26D3ClN2O5S
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SMILES
NS(=O)(C1=C(C=CC(CC(C([2H])([2H])[2H])NCCOC2=C(C=CC=C2)OCC)=C1)OC)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Novotna A, et al. Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chemico-biological interactions. 2014 Feb 05;208:64-76. [Content Brief]
[2]. Krasulova K, et al. Enantiospecific effects of chiral drugs on cytochrome P450 inhibition in vitro. Xenobiotica; the fate of foreign compounds in biological systems. 2016;46(4):315-24. [Content Brief]
[3]. Honda K, et al. Further studies on (+/-)-YM-12617, a potent and selective alpha 1-adrenoceptor antagonist and its individual optical enantiomers. Naunyn-Schmiedeberg's archives of pharmacology. 1987 Sep;336(3):295-302. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Tamsulosin-d3 hydrochloride Related Classifications
HY-B0661CS Related Classifications
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