Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
activity-based protein profiling
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "activity-based protein profiling" in MCE Product Catalog:
Target:
Research Areas:
PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of EGFR. PF-06672131 can be used for activity-based protein profiling studies .
Cat. No.: HY-126943
CAS No.: 930772-88-6
Target:
Research Areas:
SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC50 of less than 5 μM .
Target:
Research Areas:
JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments .
Cat. No.: HY-125384
CAS No.: 1628345-10-7
Target:
Research Areas:
ARN14686 is an activity-based protein profiling (ABPP) probe. ARN14686 inhibits hNAAA with high potency (IC50=0.006 μM). ARN14686 interacts with NAAA via covalent binding to the N-terminal cysteine. ARN14686 binds only to the catalytically active form of NAAA, and may serve therefore as an efficient activity-based probe .
Cat. No.: HY-185905
CAS No.: 1811556-64-5
Target:
Research Areas:
TTAMRA-FP is an activity-based probe for serine hydrolases (Serine Hydrolase) that irreversibly and covalently labels the active-site serine of catalytically active serine hydrolases. TTAMRA-FP can be used for activity-based protein profiling of serine hydrolases and related studies on the activity of osteoarthritis-associated proteases .
Cat. No.: HY-185904
CAS No.: 1811556-65-6
Target:
Research Areas:
Desthiobiotin-FP is a covalent activity-based probe used for labeling, detecting and enriching active serine hydrolases in complex protein samples. Desthiobiotin-FP combines a fluorophosphonate (FP) reactive group with a desthiobiotin tag for affinity pull-down. Desthiobiotin-FP enables activity profiling of serine- and cysteine-based enzymes .
Cat. No.: HY-183740
CAS No.: 3020685-33-7
Synonyms: N-Acryloylindole-alkyne
Target:
Research Areas:
NAIA (N-Acryloylindole-alkyne) is a cysteine-reactive probe. NAIA can be used as an imaging agent, proteome profiling agent, and covalent ligand screening tool .
Cat. No.: HY-129473
CAS No.: 82422-62-6
JCP678 is a selective inhibitor of Staphylococcus aureus serine hydrolase (FphF). JCP678 blocks the labeling of FphF by serine-reactive activity probes. JCP678 is applicable to research related to Staphylococcus aureus infections .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
