4 Results for "

alpha-hemolysin

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "alpha-hemolysin" in MCE Product Catalog:

Schisandrone
Schisandrone
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Cat. No.: HY-N2245
CAS No.: 98619-25-1
Category:  

Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

CD74

Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .
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Tosatoxumab
Tosatoxumab
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Cat. No.: HY-P99551
CAS No.: 1374419-41-6
Synonyms: KBSA301; AR-301

Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes alpha-toxin (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent. Recommend Isotope Control: Human IgG1 lambda1, Isotype Control (HY-P99992) .
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H052
H052
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Cat. No.: HY-173526
CAS No.: 2886748-00-9
Target:  

Bacterial Calcium Channel

Research Areas:  

Infection

H052 is a selective Staphylococcus aureus α-hemolysin (Hla) inhibitor. H052 binds to Hla monomers, disrupts the interaction with host cell membranes to block pore formation, inhibiting calcium ion influx, cytotoxicity, and inflammatory responses. H052 exhibits potency (EC50=30 nM in U937 cells) against Hla-induced calcium influx. H052 is promising for research of lung infections caused by S. aureus .
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Poly(U)
Poly(U)
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Cat. No.: HY-131920
CAS No.: 27416-86-0
Synonyms: Polyuridylic acid
Poly (U) (Polyuridylic acid) is an RNA chain that exists in a disordered extended state at room temperature and serves as a TLR7 ligand. Poly (U) produces distinguishable blocking effects when transported through α-hemolysin nanopores. Poly (U) forms a triple helix with adenosine or adenosine monophosphate, thereby significantly promoting the nucleotide bond condensation reaction between adenosine monophosphate and adenosine, while exerting minimal effects on other nucleosides. When conjugated with cationic lipids, Poly (U) specifically stimulates plasmacytoid dendritic cells to produce type I interferons .
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