98619-25-1
Chemical Structure
Schisandrone
- CAS. Nr.: 98619-25-1
- Formula:C21H24O5
- Molecular Weight:356.41
IUPAC Name: (2S,3S,4R)-4-(3,4-dimethoxyphenyl)-7-hydroxy-6-methoxy-2,3-dimethyl-3,4-dihydronaphthalen-1(2H)-one
InChIKey: DRKPZVVNEGETTG-XAAFQQQXSA-N
SMILES: O=C1[C@@H](C)[C@@H](C)[C@H](C2=CC=C(OC)C(OC)=C2)C3=C1C=C(O)C(OC)=C3
Biological Activity: Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera[1]. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia[2].
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Schisandrone | 99.78% | Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia. | ||||||||||||||||||||
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References
- [1]. Lian-niang, L., et al. Schisandrone, a New 4-Aryltetralone Lignan fromSchisandra sphenanthera. Planta Medica, 1985, 51(03), 217–219.
- [2]. Qi Y, et al. An inhibitory effect of schisandrone on 伪-hemolysin expression to combat methicillin-resistant staphylococcus aureus infections. World J Microbiol Biotechnol. 2022 Nov 8;39(1):3. [Content Brief]
