27416-86-0
Chemical Structure
Poly(U)
Synonym(s): Polyuridylic acid
- CAS No.: 27416-86-0
- Formula:(C9H13N2O9P)x
- Molecular Weight:N/A
SMILES: O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2)NC1=O.[n]
Biological Activity: Poly (U) (Polyuridylic acid) is an RNA chain that exists in a disordered extended state at room temperature and serves as a TLR7 ligand. Poly (U) produces distinguishable blocking effects when transported through α-hemolysin nanopores. Poly (U) forms a triple helix with adenosine or adenosine monophosphate, thereby significantly promoting the nucleotide bond condensation reaction between adenosine monophosphate and adenosine, while exerting minimal effects on other nucleosides. When conjugated with cationic lipids, Poly (U) specifically stimulates plasmacytoid dendritic cells to produce type I interferons[1][2][3].
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Poly(U) | Poly (U) (Polyuridylic acid) is an RNA chain that exists in a disordered extended state at room temperature and serves as a TLR7 ligand. Poly (U) produces distinguishable blocking effects when transported through α-hemolysin nanopores. Poly (U) forms a triple helix with adenosine or adenosine monophosphate, thereby significantly promoting the nucleotide bond condensation reaction between adenosine monophosphate and adenosine, while exerting minimal effects on other nucleosides. When conjugated with cationic lipids, Poly (U) specifically stimulates plasmacytoid dendritic cells to produce type I interferons. | |||||||||||||||||||||
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- [1]. Akeson M, et al. Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules[J]. Biophysical journal, 1999, 77(6): 3227-3233. [Content Brief]
- [2]. Sugiyama T, et al. Immunoadjuvant effects of polyadenylic: polyuridylic acids through TLR3 and TLR7[J]. International immunology, 2008, 20(1): 1-9. [Content Brief]
- [3]. Sulston J, et al. Specificity of oligonucleotide synthesis directed by polyuridylic acid[J]. Proceedings of the National Academy of Sciences, 1968, 60(2): 409-415.
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