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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
c-Kit Receptor
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "c-Kit Receptor" in MCE Product Catalog:
161
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib has limited permeability to the blood-brain barrier, primarily through ABCB1 .
161
161 Publications Verification
Cat. No.: HY-16749A
CAS No.: 2040295-03-0
Synonyms: PLX-3397 hydrochloride
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .
4
4 Cited Publications
Research Areas:
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
3
Research Areas:
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
2
2 Cited Publications
Cat. No.: HY-P80619
Synonyms: Kit; SCFR; Mast/stem cell growth factor Receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117
1
1 Cited Publications
Synonyms: M4205; IDRX-42
Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models .
Cat. No.: HY-P99488
CAS No.: 2574591-89-0
Synonyms: JSP-191; AMG-191
Target:
Research Areas:
Cat. No.: HY-177275
CAS No.: 932401-20-2
c-Kit Receptor modulator-1 (Compound #22) is a c-Kit Receptor modulator. c-Kit Receptor modulator-1 can be used for malignant cancers such as canine mastocytoma, human gastrointestinal stromal tumor and small cell lung cancer research .
Cat. No.: HY-16749R
CAS No.: 1029044-16-3
Synonyms: PLX-3397 (Standard)
Target:
Research Areas:
Pexidartinib (Standard) is the analytical standard of Pexidartinib. This product is intended for research and analytical applications. Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity .
Cat. No.: HY-13894R
CAS No.: 146535-11-7
Synonyms: AG1296 (Standard)
Target:
Research Areas:
Tyrphostin AG1296 (Standard) is the analytical standard of Tyrphostin AG1296. This product is intended for research and analytical applications. Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
Cat. No.: HY-16749AR
CAS No.: 2040295-03-0
Synonyms: PLX-3397 hydrochloride (Standard)
Target:
Research Areas:
Pexidartinib (hydrochloride) (Standard) is the analytical standard of Pexidartinib (hydrochloride). This product is intended for research and analytical applications. Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .
Cat. No.: HY-117873
CAS No.: 1613437-66-3
Target:
Research Areas:
KBP-7018 is an orally active, tyrosine kinase-selective multi-kinase inhibitor with an IC50 value of 10 nM against c-KIT, 7.6 nM against RET, and 25 nM against human PDGFR. KBP-7018 improves survival rates in a mouse model of pulmonary fibrosis. KBP-7018 can be used in research related to idiopathic pulmonary fibrosis .
Cat. No.: HY-117873A
CAS No.: 1613437-67-4
Target:
Research Areas:
KBP-7018 hydrochloride is an orally active, tyrosine kinase-selective multi-kinase inhibitor with an IC50 value of 10 nM against c-KIT, 7.6 nM against RET, and 25 nM against human PDGFR. KBP-7018 hydrochloride improves survival rates in a mouse model of pulmonary fibrosis. KBP-7018 hydrochloride can be used in research related to idiopathic pulmonary fibrosis .
Cat. No.: HY-P85841
Synonyms: C Kit; c-Kit; c-Kit Ligand; CD117; Kit; Kit Ligand; Kit oncogene; Kit proto oncogene Receptor tyrosine kinase; Kit_HUMAN; Mast cell growth factor Receptor; Mast/stem cell growth factor Receptor Kit; MGF; p145 c-Kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble Kit variant 1; Steel Factor Receptor; Stem cell factor Receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v Kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v Kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Cat. No.: HY-P706024
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Mast/stem cell growth factor Receptor Kit; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; SCFR
Species:
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Cat. No.: HY-P706025
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Mast/stem cell growth factor Receptor Kit; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; SCFR
Species:
Source:
Cat. No.: HY-P706026
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Mast/stem cell growth factor Receptor Kit; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; SCFR
Species:
Source:
Cat. No.: HY-P706027
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Mast/stem cell growth factor Receptor Kit; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; SCFR
Species:
Source:
Cat. No.: HY-P702691
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor Receptor Kit; C Kit; CD117; SCFR; p145 c-Kit; proto-oncogene c-Kit; piebald trait protein; soluble Kit variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
