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cardiac defect

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By Targets:	Amyloid-β (1) Autophagy (1) Drug Derivative (1) Ferroptosis (1) HIV (1) Reference Standards (1) Wnt (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Neurological Disease (1)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19987

BML-284 Maximum Cited Publications 41 Publications Verification	Wnt	Cancer
BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC₅₀ of 700 nM .

HY-N1487

Oleanonic acid 2 Publications Verification 3-Oxooleanolic acid	HIV Autophagy Ferroptosis Amyloid-β	Infection Neurological Disease Inflammation/Immunology Cancer
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .

HY-18402

2-(Methylthio)benzothiazole	Drug Derivative	Cardiovascular Disease
2-(Methylthio)benzothiazole is a derivative of 2-Mercaptobenzothiazole (HY-W017113). 2-(Methylthio)benzothiazole reduces heart rate, causes pericardial edema and deformity, delays cardiac maturation, decreases stroke volume and cardiac output, and leads to vascular structural defects in zebrafish larvae .

HY-19987A

BML-284 hydrochloride	Wnt	Cancer
BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC₅₀ of 700 nM .

HY-N8321R

5-O-Caffeoylshikimic acid (Standard)	Reference Standards Others	Cancer
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-19987R

BML-284 (Standard)	Wnt	Cancer
BML-284 (Standard) is the analytical standard of BML-284. This product is intended for research and analytical applications. BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1487

Oleanonic acid 2 Publications Verification 3-Oxooleanolic acid	Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	HIV Autophagy Ferroptosis Amyloid-β
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .

HY-N8321R

5-O-Caffeoylshikimic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Phenols Polyphenols Plants Source Classification	Reference Standards Others
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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cardiac defect

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Natural
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