2. Stem Cell/Wnt
  3. Wnt
  4. BML-284 hydrochloride

BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.

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CAS No. : 2095432-75-8

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BML-284 hydrochloride Related Antibodies

Top Publications Citing Use of Products

41 Publications Citing Use of MCE BML-284 hydrochloride

WB
Cell Imaging/Staining
RT-PCR
IF
In Vivo Efficacy Study

    BML-284 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2023 Aug 25;9(1):312.  [Abstract]

    Protein level of β-catenin, PPARγ, and GAPDH for RCT-FAPs (FAPs isolated from supraspinatus muscle one week after tendon tears) with or without β-catenin agonist BML-284 (1 μM) treatment.

    BML-284 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2023 Aug 25;9(1):312.  [Abstract]

    The oil red staining and statistical analysis of RCT-FAPs after 7-day adipogenic induction in AIM with DMSO or BML-284 (1 μM).

    BML-284 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2023 Aug 25;9(1):312.  [Abstract]

    Relative mRNA expression level of adipogenic genes for RCT-FAPs after 7-day adipogenic induction in AIM with DMSO or BML-284 (1 μM).

    BML-284 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2023 Aug 25;9(1):312.  [Abstract]

    Immunofluorescence staining of perilipin1 for supraspinatus muscles from the DMSO group and BML-284 (1 μM) group.

    BML-284 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2023 Aug 25;9(1):312.  [Abstract]

    Gross appearance of supraspinatus muscles from the DMSO and BML-284 (1 μM) treatment groups.

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    Description

    BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM[1].

    IC50 & Target

    EC50: 700 nM (wnt signaling)[1]
    In Vitro

    BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group[1].
    BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    BML-284 hydrochloride Related Antibodies

    Western Blot Analysis[1]

    Cell Line: Human gastric cancer cell lines MNK45 and AGS
    Concentration: 10 µM
    Incubation Time: 24 hours
    Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.
    In Vivo

    BML-284 hydrochloride (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    386.83

    Formula

    C19H19ClN4O3
    CAS No.
    SMILES

    NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    BML-284 hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BML-2842095432-75-8BML284BML 284WntTCFMNK45AGSE-cadherinN-cadherinmalformed phenotypecardiac defectInhibitorinhibitorinhibit

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