1. Stem Cell/Wnt
  2. Wnt
  3. BML-284 hydrochloride

BML-284 hydrochloride 

Cat. No.: HY-19987A
Handling Instructions

BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.

For research use only. We do not sell to patients.

BML-284 hydrochloride Chemical Structure

BML-284 hydrochloride Chemical Structure

CAS No. : 2095432-75-8

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Description

BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM[1].

IC50 & Target

EC50: 700 nM (wnt signaling)[1]

In Vitro

BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group[1].
BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human gastric cancer cell lines MNK45 and AGS
Concentration: 10 µM
Incubation Time: 24 hours
Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.
In Vivo

BML-284 hydrochloride (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

386.83

Formula

C₁₉H₁₉ClN₄O₃

CAS No.

2095432-75-8

SMILES

NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BML-284BML284BML 284WntTCFMNK45AGS E-cadherinN-cadherinmalformed phenotypecardiac defectInhibitorinhibitorinhibit

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Product Name:
BML-284 hydrochloride
Cat. No.:
HY-19987A
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