4 Results for "

cell wall integrity pathway

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "cell wall integrity pathway" in MCE Product Catalog:

N-Acetylmuramic acid
N-Acetylmuramic acid
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Cat. No.: HY-W009274
CAS No.: 10597-89-4
Synonyms: MurNAc; NAMA
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

p38 MAPK NF-κB Bacterial

N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity . N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme . N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape . N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active .
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Antifungal agent 18
Antifungal agent 18
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Cat. No.: HY-139903
CAS No.: 2572713-30-3
Purity:  98.08%
Target:  

Fungal Calcineurin p38 MAPK

Research Areas:  

Infection

Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes .
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2,5-Dimethylcyclohexanol
2,5-Dimethylcyclohexanol
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Cat. No.: HY-W160358
CAS No.: 3809-32-3
Category:  

Natural Products Cyperus esculentus L. Cyperaceae Plants

Target:  

SARS-CoV Virus Protease Fungal Apoptosis Reactive Oxygen Species (ROS) ATP Synthase Glutathione Peroxidase SOD p38 MAPK

2,5-Dimethylcyclohexanol, a volatile organic compound, is a fatty acid that can be isolated from Amphora sp.. 2,5-Dimethylcyclohexanol has significant antineoplastic and antiviral activities with inhibition of SARS-CoV-2 Mpro. 2,5-Dimethylcyclohexanol also has potent antifungal activity against Pseudogymnoascus destructans. 2,5-Dimethylcyclohexanol compromises cell wall and membrane integrity while perturbing energy metabolism, increases the levels of ROS, ATP, Superoxide anion and GSH, and decreases CAT and SOD activities. And 2,5-Dimethylcyclohexanol alters virulence ribosomal genes expression, and disrupts the MAPK signaling pathways, inducing fungal cell apoptosis .
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NVP-BHS345
NVP-BHS345
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Cat. No.: HY-183393
CAS No.: 1798292-13-3
Target:  

mTOR Fungal

Research Areas:  

Infection

NVP-BHS345 is an ATP-competitive TORC1/TORC2 inhibitor with an IC50 of 1 μM for both targets in yeast. NVP-BHS345 acutely inhibits TORC1/TORC2 kinase activity, even in genetically engineered TOR1 M2282T Saccharomyces cerevisiae strains. NVP-BHS345 also reduces the phosphorylation levels of Ser-232/Ser-233 sites in Sch9, Ypk1/Ypk2 and Rps6, and induces hyperphosphorylation of Slt2 and activation of the cell wall integrity pathway. NVP-BHS345 causes depolarization of the actin cytoskeleton, blocks fluid-phase endocytosis, prevents the accumulation of vacuolar lipophilic dyes, and regulates the phosphorylation levels of Ent1, Pan1, Prk1, Akl1 and other cellular proteins .
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