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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
dacomitinib
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "dacomitinib" in MCE Product Catalog:
29
29 Cited Publications
Synonyms: PF-00299804; PF-299804
Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .
29
29 Cited Publications
Synonyms: PF-00299804 hydrate; PF-299804 hydrate
Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan-ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC) .
Referencia número: HY-13272R
No. CAS: 1110813-31-4
Synonyms: PF-00299804 (Standard); PF-299804 (Standard)
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Dacomitinib (Standard) is the analytical standard of Dacomitinib. This product is intended for research and analytical applications. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .
Referencia número: HY-13272S2
Synonyms: PF-00299804-d10 dihydrochloride; PF-299804-d10 dihydrochloride
Referencia número: HY-13272S3
Synonyms: PF-00299804-d10; PF-299804-d10
Referencia número: HY-167948
No. CAS: 1262034-38-7
Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC).
Referencia número: HY-Z4784
No. CAS: 2119689-75-5
Synonyms: dacomitinib Impurity SFXJ
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Dacomitinib impurity 8 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z4785
No. CAS: 2117703-26-9
Synonyms: dacomitinib Impurity SFAJ
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Dacomitinib impurity 9 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z4779
No. CAS: 2803478-66-0
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Dacomitinib impurity 4 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z4780
No. CAS: 2190490-31-2
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Dacomitinib impurity 3 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z4786
No. CAS: 2803478-55-7
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Dacomitinib impurity 1 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z4787
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Dacomitinib impurity 11 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z6413
No. CAS: 2803456-91-7
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Dacomitinib impurity 16 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z6415
No. CAS: 1454307-45-9
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Dacomitinib impurity 14 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z6416
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Dacomitinib impurity 13 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-Z6417
No. CAS: 2803451-99-0
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Dacomitinib impurity 12 is an impurity of Dacomitinib (HY-13272).
Referencia número: HY-160828
No. CAS: 2468202-15-3
Synonyms: PF-05199265
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O-Desmethyl dacomitinib (PF-05199265) is the major circulating metabolite of dacomitinib (HY-13272) and acts as a pan-epidermal growth factor receptor (ErbB) tyrosine kinase inhibitor. O-Desmethyl dacomitinib exhibits a much lower exposure level than dacomitinib in the body. O-Desmethyl dacomitinib is highly dependent on the enzymatic activity of CYP2D6 for its formation .
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