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Cat. No.: HY-160828

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O-Desmethyl dacomitinib

(Synonyms: PF-05199265)

O-Desmethyl dacomitinib (PF-05199265) is the major circulating metabolite of dacomitinib (HY-13272) and acts as a pan-epidermal growth factor receptor (ErbB) tyrosine kinase inhibitor. O-Desmethyl dacomitinib exhibits a much lower exposure level than dacomitinib in the body. O-Desmethyl dacomitinib is highly dependent on the enzymatic activity of CYP2D6 for its formation.

For research use only. We do not sell to patients.

CAS No.: 2468202-15-3
Formula: C₂₃H₂₃ClFN₅O₂
Molecular Weight:455.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

O-Desmethyl dacomitinib Chemical Structure

CAS No.: 2468202-15-3

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

All EGFR Isoforms :

Chemical Information

CAS No. 2468202-15-3
Molecular Weight 455.91
Formula C₂₃H₂₃ClFN₅O₂
SMILES

OC(C(NC(/C=C/CN1CCCCC1)=O)=C2)=CC3=C2C(NC4=CC(Cl)=C(C=C4)F)=NC=N3
Synonyms

PF-05199265
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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O-Desmethyl dacomitinib

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

O-Desmethyl dacomitinib Related Classifications

HY-160828 Related Classifications