2468202-15-3
Chemical Structure
O-Desmethyl dacomitinib
Synonym(s): PF-05199265
- CAS No.: 2468202-15-3
- Formula:C23H23ClFN5O2
- Molecular Weight:455.91
IUPAC Name: (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide
InChIKey: VFBCTMFFOJGSLU-SNAWJCMRSA-N
SMILES: OC(C(NC(/C=C/CN1CCCCC1)=O)=C2)=CC3=C2C(NC4=CC(Cl)=C(C=C4)F)=NC=N3
Biological Activity: O-Desmethyl dacomitinib (PF-05199265) is the major circulating metabolite of dacomitinib (HY-13272) and acts as a pan-epidermal growth factor receptor (ErbB) tyrosine kinase inhibitor. O-Desmethyl dacomitinib exhibits a much lower exposure level than dacomitinib in the body. O-Desmethyl dacomitinib is highly dependent on the enzymatic activity of CYP2D6 for its formation[1].
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O-Desmethyl dacomitinib | O-Desmethyl dacomitinib (PF-05199265) is the major circulating metabolite of dacomitinib (HY-13272) and acts as a pan-epidermal growth factor receptor (ErbB) tyrosine kinase inhibitor. O-Desmethyl dacomitinib exhibits a much lower exposure level than dacomitinib in the body. O-Desmethyl dacomitinib is highly dependent on the enzymatic activity of CYP2D6 for its formation. | |||||||||||||||||||||
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Keywords
