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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
excitatory action
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "excitatory action" in MCE Product Catalog:
Cat. No.: HY-164795
CAS No.: 1849603-79-7
Research Areas:
SBI-810 is a blood-brain barrier-permeable NTSR1 modulator. SBI-810 promotes the recruitment of β-arrestin-2 to NTSR1 and antagonizes NTSR1-mediated Gq activation. SBI-810 inhibits excitatory synaptic transmission, NMDA receptor and extracellular signal-regulated kinase (ERK) signaling in spinal nociceptive neurons, reduces surface expression of Nav1.7 and action potential firing in primary sensory neurons, and attenuates C-fiber responses. SBI-810 effectively alleviates acute and chronic pain in various rodent models through peripheral and central modulation. SBI-810 is applicable to research related to multiple pain disorders .
Cat. No.: HY-164795A
CAS No.: 2772746-58-2
Research Areas:
SBI-810 hydrochloride is a blood-brain barrier-permeable NTSR1 modulator. SBI-810 hydrochloride promotes the recruitment of β-arrestin-2 to NTSR1 and antagonizes NTSR1-mediated Gq activation. SBI-810 hydrochloride inhibits excitatory synaptic transmission, NMDA receptor and extracellular signal-regulated kinase (ERK) signaling in spinal nociceptive neurons, reduces surface expression of Nav1.7 and action potential firing in primary sensory neurons, and attenuates C-fiber responses. SBI-810 hydrochloride effectively alleviates acute and chronic pain in various rodent models through peripheral and central modulation. SBI-810 hydrochloride is applicable to research related to multiple pain disorders .
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DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .
Cat. No.: HY-P3712
CAS No.: 127122-98-9
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Cat. No.: HY-167822
CAS No.: 1531600-36-8
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Caramboxin is a phenylalanine-like α-amino acid neurotoxin found in star fruit (Averrhoa carambola) with glutamatergic ionotropic action. Caramboxin activates NMDA, AMPA, and kainate receptors while inhibiting GABA binding to synaptic membranes, shifting the CNS toward an excitatory state and exerting neurotoxic effects linked to star fruit ingestion. Caramboxin can be used for research on neurotoxicity and as a reference standard for toxicological studies .
Cat. No.: HY-P10979
CAS No.: 116786-35-7
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Cat. No.: HY-108576
CAS No.: 113168-57-3
Synonyms: DuP 996 dihydrochloride
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Linopirdine dihydrochloride is a agonist of capsaicin receptor TRPV1. Linopirdine increases the intracellular calcium concentration in HEK293 cells. Linopirdine dihydrochloride exerts an excitatory action on mammalian nociceptors .
Cat. No.: HY-100743R
CAS No.: 6323-99-5
Synonyms: 2-Amino-4-phosphonobutyric acid (Standard)
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DL-AP4 (Standard) is the analytical standard of DL-AP4. This product is intended for research and analytical applications. DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
