1531600-36-8
Chemical Structure
Caramboxin
- CAS No.: 1531600-36-8
- Formula:C11H13NO6
- Molecular Weight:255.22
InChIKey: DYJIDGJHOLTGBO-ZETCQYMHSA-N
SMILES: OC([C@@H](N)CC1=C(C(O)=CC(OC)=C1)C(O)=O)=O
Biological Activity: Caramboxin is a phenylalanine-like α-amino acid neurotoxin found in star fruit (Averrhoa carambola) with glutamatergic ionotropic action. Caramboxin activates NMDA, AMPA, and kainate receptors while inhibiting GABA binding to synaptic membranes, shifting the CNS toward an excitatory state and exerting neurotoxic effects linked to star fruit ingestion. Caramboxin can be used for research on neurotoxicity and as a reference standard for toxicological studies[1][2].
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Caramboxin | 99.62% | Caramboxin is a phenylalanine-like α-amino acid neurotoxin found in star fruit (Averrhoa carambola) with glutamatergic ionotropic action. Caramboxin activates NMDA, AMPA, and kainate receptors while inhibiting GABA binding to synaptic membranes, shifting the CNS toward an excitatory state and exerting neurotoxic effects linked to star fruit ingestion. Caramboxin can be used for research on neurotoxicity and as a reference standard for toxicological studies. | ||||||||||||||||||||
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References
- [1]. Derrien B, et al. Enantioselective Total Synthesis of the Neurotoxin Caramboxin. The Journal of organic chemistry. 2024 May 03;89(9):6489-6493. [Content Brief]
- [2]. Yasawardene P, et.al. Seneviratne SL. Mechanisms of star fruit (Averrhoa carambola) toxicity: A mini-review. Toxicon. 2020 Nov;187:198-202. [Content Brief]
