48 Results for "

human CD40

" in MedChemExpress (MCE) Product Catalog:
Products (48)

48 Results for "human CD40" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P72907
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD40 ligand; CD40-L; TRAP; CD154; sCD40L; TNFSF5
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P990133

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) blocks the interactionbetween CD154 and CD40. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) can be used for the researches of inflammation and immunology, such as colitis and transplant .
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1
1 Cited Publications
Cat. No.: HY-P7144
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuCD40L; CD154; TRAP; TNFSF5; CD40LG; CD40-L
Species:  
Source:  
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Cat. No.: HY-P99325
CAS No.: 252662-47-8
Synonyms: IDEC-131; Anti-human CD40 ligand Recombinant Antibody

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohn’s disease .
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Cat. No.: HY-P99315
CAS No.: 220651-94-5
Synonyms: BG 9588; Anti-human CD40L Recombinant Antibody; Hu5c8

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P99167
CAS No.: 903512-50-5
Synonyms: HCD122

Target:  

TNF Receptor

Research Areas:  

Cancer

Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .
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Cat. No.: HY-P99603
CAS No.: 1629760-27-5
Synonyms: SEA-CD40

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Cifurtilimab (SEA-CD40) is an agonistic nonfucosylated, human IgG1 monoclonal antibody directed against CD40. Cifurtilimab shows antitumor activities .
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Cat. No.: HY-P99321
CAS No.: 299423-37-3
Synonyms: BMS 224819; Chi220; Anti-human CD40 Recombinant Antibody

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Teneliximab (BMS-224819) is a chimeric monoclonal antibody, blocks the CD40-CD40L interaction. Teneliximab (BMS-224819) has partial agonist activity resulting in some signaling through CD40 and peripheral B cell depletion .
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Cat. No.: HY-P99257
CAS No.: 1453067-91-8
Synonyms: ASKP 1240

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd: 0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection .
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Cat. No.: HY-P990726
CAS No.: 2765071-95-0
Synonyms: KPL-404

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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Cat. No.: HY-P990860

Target:  

TNF Receptor

Research Areas:  

Cancer

Anti-CD40 Antibody (G28.5) is a kind of mouse IgG1 κ chimeric agonistic antibody, targeting to human CD40. Anti-CD40 Antibody (G28.5) can activate CD40 signaling and promote anti-tumor T cell responses. Anti-CD40 Antibody (G28.5) can be used for the research of cancer, such as endometrial cancer .
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Cat. No.: HY-174738
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CD40 mRNA encodes the human CD40 molecule (CD40) protein, a member of the TNF-receptor superfamily. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
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Cat. No.: HY-RS02246
Research Areas:  

Others

CD40 Human Pre-designed siRNA Set A contains three designed siRNAs for CD40 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991525
CAS No.: 2923542-55-4

Target:  

Fc Receptor (FcR)

Research Areas:  

Cancer

2141-V11 is an Fc-engineered agonistic antibody against human CD40 with selectively enhanced binding affinity for human FcγRIIB. 2141-V11 drives CD40 multimerization and agonistic signal transduction, activates dendritic cells, promotes antigen cross-presentation and CD8 + T cell priming, induces tertiary lymphoid structure formation, increases leukocyte infiltration, and mediates local and abscopal anti-tumor effects, systemic immune activation and immune memory. 2141-V11 exhibits extremely low systemic toxicity upon intratumoral or intravesical administration, with no dose-limiting toxicity observed at the tested intratumoral doses, whereas high-dose systemic administration induces thrombocytopenia and elevated transaminases. 2141-V11 can be used in research related to breast cancer, melanoma, BCG-unresponsive non-muscle invasive bladder cancer, and recurrent malignant glioma .
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Cat. No.: HY-P991557

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

ABI793 is a human IgG1 anti-human CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection .
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Cat. No.: HY-P991510

Target:  

TNF Receptor

Research Areas:  

Cancer

CDX-1140 is a fully human IgG monoclonal antibody and CD40 agonist, with a Kd value of 0.01 nM against human targets. The epitope of CDX-1140 locates at CD40 CRD1 and avoids the CD40L binding site. It activates DCs and B cells, drives NF-κB reporter gene activation, exhibits agonist activity independent of FcR cross-linking, and shows a synergistic effect with recombinant CD40L . CDX-1140 does not induce systemic cytokine release, exerts direct and immune-mediated anti-tumor activity in tumor xenografts, and has favorable safety profiles. When used as a local vaccine adjuvant in combination with 6MHP+mBRAF+poly-ICLC, CDX-1140 increases the number of DC-LAMP + DCs and induces Th1 CD4 + responses in high-risk melanoma. CDX-1140 can be used in studies related to B-cell lymphoma, bladder cancer and high-risk melanoma .
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Cat. No.: HY-120471
CAS No.: 1259522-94-5
Target:  

PI3K

Research Areas:  

Inflammation/Immunology

AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy .
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Cat. No.: HY-P991126
CAS No.: 3014361-59-9
Synonyms: YH003

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Ciltistotug is a monoclonal antibody targeting human CD40 (TNFRSF5). Ciltistotug activates immune cells after binding to CD40, exerting immunostimulatory and antitumor activities. Ciltistotug is promising for research of cancer immunotherapy .
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Cat. No.: HY-P990044
CAS No.: 2642171-59-1
Synonyms: LVGN-7409

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Dalnicastobart (LVGN-7409) is a human IgG1κ antibody targeting CD40/TNFRSF5 .
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Cat. No.: HY-174737
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CD40LG mRNA encodes the human CD40 ligand (CD40LG) protein, a protein that is expressed on the surface of T cells. CD40LG regulates B cell function by engaging CD40 on the B cell surface.
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