2923542-55-4
Chemical Structure
Biological Activity: 2141-V11 is an Fc-engineered agonistic antibody against human CD40 with selectively enhanced binding affinity for human FcγRIIB. 2141-V11 drives CD40 multimerization and agonistic signal transduction, activates dendritic cells, promotes antigen cross-presentation and CD8+ T cell priming, induces tertiary lymphoid structure formation, increases leukocyte infiltration, and mediates local and abscopal anti-tumor effects, systemic immune activation and immune memory. 2141-V11 exhibits extremely low systemic toxicity upon intratumoral or intravesical administration, with no dose-limiting toxicity observed at the tested intratumoral doses, whereas high-dose systemic administration induces thrombocytopenia and elevated transaminases. 2141-V11 can be used in research related to breast cancer, melanoma, BCG-unresponsive non-muscle invasive bladder cancer, and recurrent malignant glioma[1][2][3][4].
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2141-V11 | 99.04% | 2141-V11 is an Fc-engineered agonistic antibody against human CD40 with selectively enhanced binding affinity for human FcγRIIB. 2141-V11 drives CD40 multimerization and agonistic signal transduction, activates dendritic cells, promotes antigen cross-presentation and CD8+ T cell priming, induces tertiary lymphoid structure formation, increases leukocyte infiltration, and mediates local and abscopal anti-tumor effects, systemic immune activation and immune memory. 2141-V11 exhibits extremely low systemic toxicity upon intratumoral or intravesical administration, with no dose-limiting toxicity observed at the tested intratumoral doses, whereas high-dose systemic administration induces thrombocytopenia and elevated transaminases. 2141-V11 can be used in research related to breast cancer, melanoma, BCG-unresponsive non-muscle invasive bladder cancer, and recurrent malignant glioma. | ||||||||||||||||||||
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- [1]. Osorio JC, et al. Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer. Cancer cell. 2025 Oct 13;43(10):1902-1916.e9. [Content Brief]
- [2]. Knorr DA, et al. Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity. Proceedings of the National Academy of Sciences of the United States of America. 2018 Oct 23;115(43):11048-11053. [Content Brief]
- [3]. Osorio JC, et al. Abstract CT203: Fc‑optimized anti‑CD40 agonist antibody 2141‑V11 for BCG‑unresponsive non‑muscle invasive bladder cancer: Updates on phase 1 study clinical outcomes and biological correlates. Cancer Res. 2025;85(8_Supplement_2):CT203.
- [4]. Desjardins A, et al. A phase 1 trial of D2C7‑it in combination with an Fc‑engineered anti‑CD40 monoclonal antibody (2141‑V11) administered intratumorally via convection‑enhanced delivery for adult patients with recurrent malignant glioma (MG). J Clin Oncol. 2022;40(16_suppl):e14015.
Keywords
