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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
human CES2
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "human CES2" in MCE Product Catalog:
Art. -Nr.: HY-E70599
Target:
Forschungsgebiete:
Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome .
Target:
Forschungsgebiete:
CES2-IN-1 (Compound 24) is a reversible and selective CES2 inhibitor (IC50: 6.72 μM for human CES2). CES2-IN-1 reduces the level of CES2 in living cells. CES2-IN-1 is effective against Irinotecan (HY-16562)-induced delayed diarrhea and DSS-induced ulcerative colitis .
Art. -Nr.: HY-RS02544
Target:
Forschungsgebiete:
CES2 Human Pre-designed siRNA Set A contains three designed siRNAs for CES2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P76192A
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cocaine esterase; Carboxylesterase 2; CE-2; CES2; ICE
Art. -Nr.: HY-155755
Forschungsgebiete:
CES2A-IN-1 (compound 20w) is a potent CES2A inhibitor with an IC50 value of 1.6 nM for human CES2A. CES2A-IN-1, a bysspectin A derivative, shows an approximately 1000-fold improvement over the lead compound bysspectin A .
Art. -Nr.: HY-173267
Target:
Forschungsgebiete:
CES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible and covalent CES2A inhibitor with an IC50 of 0.04 nM for human CES2A. CES2A-IN-2 covalently binds to CES2A by specifically targeting the catalytic serine residue (Ser-228). CES2A-IN-2 can significantly ameliorate Irinotecan-triggered gut toxicity (ITGT) without diminishing the anti-tumor effects of Irinotecan (HY-16562) in tumor-bearing mice .
Art. -Nr.: HY-176465
CAS. Nr.: 3037959-47-7
Target:
Forschungsgebiete:
CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis .
Art. -Nr.: HY-184061
CAS. Nr.: 2590661-64-4
Target:
Forschungsgebiete:
Carboxylesterase 2-IN-1 is a potent carboxylesterase CES2 inhibitor with an IC50 of 0.13 μM. Carboxylesterase 2-IN-1 blocks the hydrolysis of fluorescein diacetate by CES2 via non-competitive inhibition. Carboxylesterase 2-IN-1 also effectively inhibits adipogenesis induced in mouse preadipocytes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
