CES2A-IN-1
CES2A-IN-1 (compound 20w) is a potent CES2A inhibitor with an IC50 value of 1.6 nM for human CES2A. CES2A-IN-1, a bysspectin A derivative, shows an approximately 1000-fold improvement over the lead compound bysspectin A.
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- Formule: C23H26O4
- Masse moléculaire:366.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
hCES2A (0.0016 ± 0.00034 μM), hCES1A (7.26 ± 0.94 μM)[1]
In Vitro
hCES2A-IN-1 (compound 20w) exhibits very weak cytotoxicity to the HepG2 cells at concentration less than 10 μM[1].
hCES2A-IN-1 can inhibit hCES2A-mediated NCEN hydrolysis in living cells in a dose-dependent manner with an IC50 value of 0.052 μM, which showed significantly higher inhibition activity than Loperamide with an IC50 value of 1.44 μM[1].
hCES2A-IN-1 (compound 20w) exhibits favorable metabolic stability. The half-life of compound 20w in phase I or phase II metabolic systems in human liver microsomes are 125.96 min and 97.38 min, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Masse moléculaire 366.45
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Formule C23H26O4
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SMILES
CCCCCCC(C1=C2C=C(C3=CC(OC)=CC=C3O)OC2=CC=C1C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CES2A-IN-1 Related Classifications
HY-155755 Related Classifications
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