Carboxylesterase 2-IN-1
Carboxylesterase 2-IN-1 is a potent carboxylesterase CES2 inhibitor with an IC50 of 0.13 μM. Carboxylesterase 2-IN-1 blocks the hydrolysis of fluorescein diacetate by CES2 via non-competitive inhibition. Carboxylesterase 2-IN-1 also effectively inhibits adipogenesis induced in mouse preadipocytes.
For research use only. We do not sell to patients.
- CAS No.: 2590661-64-4
- Formula: C22H24N2O
- Molecular Weight:332.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CES2 |
Carboxylesterase 2-IN-1 (compound 26) (10-40 μM; 144 h for adipogenesis inhibition, 48 h for cytotoxicity testing) is non-toxic to 3T3-L1, Caco-2, and HepG2 cells at concentrations up to 40 μM, and potently inhibits adipogenesis and lipid droplet formation in differentiated 3T3-L1 preadipocytes, with near-complete inhibition at 40 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse 3T3-L1 preadipocytes, Caco-2 cells, HepG2 cells
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Concentration:10-40 μM (adipogenesis inhibition); 0-100 μM (cytotoxicity testing)
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Incubation Time:144 h (total adipogenesis inhibition); 48 h (cytotoxicity testing)
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Result:Showed no significant cytotoxicity to 3T3-L1, Caco-2, or HepG2 cells at concentrations up to 40 μM.
Almost completely inhibited lipid droplet formation in differentiated 3T3-L1 adipocytes at 40 μM.
Resulted in lipid droplet formation similar to the uninduced control group in differentiated 3T3-L1 adipocytes at 10 μM.
Increased lipid droplet content as the compound concentration decreased from 40 μM to 10 μM.
Chemical Information
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CAS No. 2590661-64-4
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Molecular Weight 332.44
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Formula C22H24N2O
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SMILES
O=C1N(C2CCCCC2)N=C(C1CC3=CC=CC=C3)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carboxylesterase 2-IN-1 Related Classifications
HY-184061 Related Classifications
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