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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
human PAK1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "human PAK1" in MCE Product Catalog:
Cat. No.: HY-RS09983
Target:
Research Areas:
PAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-164374
CAS No.: 445007-59-0
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .
Cat. No.: HY-RS09986
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PAK1IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184447
CAS No.: 3091508-49-2
RN193 is a type II kinase inhibitor with a human PAK1 IC50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states .
Cat. No.: HY-P71530
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PAK1; Alpha-PAK; P21 (RAC1) Activated Kinase 1; P65-PAK; P21/Cdc42/Rac1-Activated Kinase 1 (STE20 Homolog, Yeast); Non-Specific Serine/Threonine Protein Kinase; P21/Cdc42/Rac1-Activated Kinase 1 (Yeast Ste20-Related); P21-Activated Kinase 1; P21 Protein (
Cat. No.: HY-P702648
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PKN1; Protein Kinase PKN-Alpha; Prev. PRKCL1; PAK-1; PAK1; Non-Specific Serine/Threonine Protein Kinase; PRK1; Serine/Threonine Protein Kinase N; PKN; Protein Kinase C-Related Kinase 1; Protein Kinase C-Like 1; Protein-Kinase C-Related Kinase 1; DBK; Seri
Species:
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Cat. No.: HY-P705857
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PKN1; Protein Kinase PKN-Alpha; Prev. PRKCL1; PAK-1; PAK1; Non-Specific Serine/Threonine Protein Kinase; PRK1; Serine/Threonine Protein Kinase N; PKN; Protein Kinase C-Related Kinase 1; Protein Kinase C-Like 1; Protein-Kinase C-Related Kinase 1; DBK; Seri
Species:
Source:
Cat. No.: HY-111103
CAS No.: 2196199-00-3
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Research Areas:
CZh226 is a selective PAK4 inhibitor with an IC50 of 0.0111 μM and a Ki of 0.009 μM. CZh226 functionally inhibits PAK4 activity and reduces the phosphorylation level of downstream signaling molecules. CZh226 inhibits the migration and invasion of tumor cells. CZh226 is applicable to lung cancer-related research .
Cat. No.: HY-182357
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Research Areas:
PAK1-IN-3 is a PAK1 inhibitor with an IC50 of 10 nM, an IC50 of 20 nM against PAK2, and an IC50 of 1079 nM against hERG potassium channels. PAK1-IN-3 forms a salt bridge with Asp106 in PAK1 via a properly positioned tertiary amine. PAK1-IN-3 inhibits PAK2 and hERG potassium channels .
Cat. No.: HY-183941
CAS No.: 713080-84-3
SPU-106 is a p21 activated kinase 4 (PAK4) inhibitor with a target IC50 of 21.36 μM. SPU-106 selectively binds to the C-terminal kinase domain of PAK4 to inhibit its kinase activity. SPU-106 inhibits the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. SPU-106 inhibits invasion of gastric cancer cells and lacks cytotoxicity against cancer cells. SPU-106 can be used for the research of gastric cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
