445007-59-0
445007-59-0
Chemical Structure
AK963/40708899
- CAS No.: 445007-59-0
- Formula:C16H18N2O
- Molecular Weight:254.33
InChIKey: BAIIKMBZYOWCBK-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C)=CC=C1C)NC2=CC=CC(C)=C2
Biological Activity: AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].
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AK963/40708899 | AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways. | |||||||||||||||||||||
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