3091508-49-2
Chemical Structure
RN193
- CAS 番号: 3091508-49-2
- Formula:C30H32N6O3
- Molecular Weight:524.61
InChIKey: PJYWYYAQLNEQNB-UHFFFAOYSA-N
SMILES: O=C(C1(CC1)C(NC2=CC(C(C)C)=CC=C2)=O)NC3=CC(C4=CNC5=NC=NC(N6CCOCC6)=C54)=CC=C3
Biological Activity: RN193 is a type II kinase inhibitor with a human PAK1 IC50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states[1].
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RN193 | RN193 is a type II kinase inhibitor with a human PAK1 IC50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states. | |||||||||||||||||||||
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Keywords
