713080-84-3
713080-84-3
Chemical Structure
SPU-106
- CAS No.: 713080-84-3
- Formula:C22H17N3O3S
- Molecular Weight:403.45
InChIKey: AXKJASDHGOGLLB-UHFFFAOYSA-N
SMILES: O=C1C=C(N=C(N1C2=CC=CC=C2)SCC(NC3=CC4=C(C=CC=C4)C=C3)=O)O
Biological Activity: SPU-106 is a p21 activated kinase 4 (PAK4) inhibitor with a target IC50 of 21.36 μM. SPU-106 selectively binds to the C-terminal kinase domain of PAK4 to inhibit its kinase activity. SPU-106 inhibits the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. SPU-106 inhibits invasion of gastric cancer cells and lacks cytotoxicity against cancer cells. SPU-106 can be used for the research of gastric cancer[1].
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SPU-106 | SPU-106 is a p21 activated kinase 4 (PAK4) inhibitor with a target IC50 of 21.36 μM. SPU-106 selectively binds to the C-terminal kinase domain of PAK4 to inhibit its kinase activity. SPU-106 inhibits the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. SPU-106 inhibits invasion of gastric cancer cells and lacks cytotoxicity against cancer cells. SPU-106 can be used for the research of gastric cancer. | |||||||||||||||||||||
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