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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
human p300
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "human p300" in MCE Product Catalog:
Referencia número: HY-RS04405
Target:
Áreas de investigación:
EP300 Human Pre-designed siRNA Set A contains three designed siRNAs for EP300 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-123009
No. CAS: 927823-01-6
Target:
HIF/HIF Prolyl-Hydroxylase Histone Acetyltransferase Apoptosis Carbonic Anhydrase VEGFR GLUT
Áreas de investigación:
KCN1 is a p300/HIF-1α interaction inhibitor with a Kd value of 345 nM for p300-CH1. KCN1 binds to the CH1 domain of p300, blocks the assembly of the p300/HIF-1α complex, and disrupts the HIF-1α-p300/CBP interaction. KCN1 inhibits cancer cell growth, induces cancer cell cycle arrest and apoptosis. KCN1 inhibits β-galactosidase activity and downregulates the expression of VEGF, Glut1, CA9 and CAIX. KCN1 exerts anticancer activity in mouse tumor xenograft models. KCN1 can be used in research related to malignant glioma, pancreatic cancer and metastatic uveal melanoma .
Referencia número: HY-P702892
Pureza: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Ep300; Histone Crotonyltransferase p300; Ep300 Lysine Acetyltransferase; Histone Butyryltransferase p300; p300; Protein Lactyltransferas p300; Histone Acetyltransferase p300; E1A-Associated Protein p300; E1A Binding Protein p300; p300 HAT; KAT3B; E1A-Bind
Referencia número: HY-P7S0575
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Ep300; Histone Crotonyltransferase p300; Ep300 Lysine Acetyltransferase; Histone Butyryltransferase p300; p300; Protein Lactyltransferas p300; Histone Acetyltransferase p300; E1A-Associated Protein p300; E1A Binding Protein p300; p300 HAT; KAT3B; E1A-Bind
Referencia número: HY-168201
No. CAS: 3105406-14-9
Áreas de investigación:
MJP6412 is a p300 and CBP PROTAC degrader that potently degrades p300 and CBP in 22Rv1 cells with DC50 values of 1.6 nM and 1.2 nM, respectively. MJP6412 downregulates the expression of AR-FL, AR-V7 and c-MYC, as well as androgen receptor target genes (KLK3, FKBP5, TMPRSS2). MJP6412 completely abolishes p300/CBP-dependent histone acetylation (H3K27Ac and H2BNTAC) and induces G1 cell cycle arrest. MJP6412 inhibits cancer cell proliferation and tumor growth. MJP6412 can be used in prostate cancer-related research .
Referencia número: HY-181957
No. CAS: 3082090-83-0
Áreas de investigación:
KB528 is a p300/CBP histone acetyltransferase (KAT) inhibitor with low nM IC50 values against human p300 and CBP, and exhibits selectivity over other KAT family members. KB528 modulates the IRF4 transcriptional network, downregulates the expression of IRF4, MYC, CAV2 and IGLL5, and reduces the protein level of IKZF3. KB528 potently induces apoptosis in multiple myeloma cells. KB528 is applicable to research related to multiple myeloma .
Referencia número: HY-181669
No. CAS: 3034595-62-2
Target:
Áreas de investigación:
P300-IN-6 is an orally active histone acetyltransferase p300 HAT domain inhibitor with human IC50 values of 7 nM. P300-IN-6 suppresses c-Myc expression, decreases H3K18ac and H3K27ac levels, and inhibits cancer cell proliferation.P300-IN-6 suppresses tumor growth in xenograft mouse models.P300-IN-6 can be used for the research of multiple myeloma .
Referencia número: HY-114510
No. CAS: 1020399-52-3
PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC50 of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia .
Referencia número: HY-187436
No. CAS: 3094841-98-9
Áreas de investigación:
CZL-105 is a highly potent, selective, and orally active p300/CBP inhibitor, with IC50 values of 0.09 μM and 0.08 μM against p300 and CBP bromodomains, respectively. CZL-105 inhibits the proliferation of OPM-2 multiple myeloma cells with an IC50 of 57 nM, and induces G0/G1 cell cycle arrest and apoptosis. CZL-105 is applicable for research related to multiple myeloma .
Referencia número: HY-P702904
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KAT2B; K(Lysine) Acetyltransferase 2B; Prev. PCAF; Histone Acetylase PCAF; P/CAF; GCN5L; p300/CBP-Associated Factor; GCN5; Spermidine Acetyltransferase KAT2B; CREBBP-Associated Factor; Histone Acetyltransferase KAT2B; CAF; Lysine Acetyltransferase 2B; His
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
