3094841-98-9
Chemical Structure
CZL-105
- CAS No.: 3094841-98-9
- Formula:C31H36FN5O4
- Molecular Weight:561.65
InChIKey: WGZCPCRWWCOGMI-RSEQLOHWSA-N
SMILES: CC1=C(C(C)=NO1)C2=CC3=NC([C@H]4N(C(CCC4)=O)C5=CC(F)=C(C=C5)OC)=C(N3C=C2)N[C@H]6CC[C@@H](CC6)OC
Biological Activity:
CZL-105 is a highly potent, selective, and orally active p300/CBP inhibitor, with IC50 values of 0.09 μM and 0.08 μM against p300 and CBP bromodomains, respectively. CZL-105 inhibits the proliferation of OPM-2 multiple myeloma cells with an IC50 of 57 nM, and induces G0/G1 cell cycle arrest and apoptosis. CZL-105 is applicable for research related to multiple myeloma[1].
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CZL-105 | CZL-105 is a highly potent, selective, and orally active p300/CBP inhibitor, with IC50 values of 0.09 μM and 0.08 μM against p300 and CBP bromodomains, respectively. CZL-105 inhibits the proliferation of OPM-2 multiple myeloma cells with an IC50 of 57 nM, and induces G0/G1 cell cycle arrest and apoptosis. CZL-105 is applicable for research related to multiple myeloma. |
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Keywords
