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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
human telomerase
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "human telomerase" in MCE Product Catalog:
5
5 Cited Publications
Target:
Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor .
Synonyms: GRN163L
Target:
Research Areas:
Imetelstat (GRN163L) is a 13-mer oligonucleotide and competitive Telomerase inhibitor. Imetelstat binds with high affinity to the template region of the RNA component of human telomerase. Imetelstat induces Apoptosis. Imetelstat is capable of selectively eliminating myelofibrosis hematopoietic stem cells. Imetelstat leads to the loss of a cancer cell's ability to maintain telomere length, resulting in the inhibition of cell proliferation .
Cat. No.: HY-105067A
CAS No.: 922174-60-5
Synonyms: GV-1001 hydrochloride
Target:
Research Areas:
Tertomotide (GV1001) hydrochloride is peptide vaccine consists a 16-aa human telomerase reverse transcriptase (hTERT) sequence. Tertomotide hydrochloride shows neuroprotective. Tertomotide hydrochloride has the potential for the research of Alzheimer's disease .
Cat. No.: HY-175103
Synonyms: β-L-dGTP sodium; L-2'-Deoxyguanosine 5'-triphosphate sodium; 2’-Deoxy-L-GTP sodium
Target:
Research Areas:
Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and an inhibitor of telomerase with a Ki of 15 μM for human enzyme .
Cat. No.: HY-148200A
Purity: 99.28%
Target:
Research Areas:
L2H2-6OTD diformic is a G-quadruplex (G-quadruplex, G4) ligand and telomerase (telomerase) inhibitor, with an IC50 of 15 nM against human telomerase. L2H2-6OTD diformic induces the formation of antiparallel G-quadruplex structures in long telomeric DNA. L2H2-6OTD diformic stabilizes the G4 structure of GD3 and enhances the immunological activity of CpG ODN. L2H2-6OTD diformic is applicable to research related to the development of G4-CpG immune adjuvants .
Cat. No.: HY-174537
Human TERT mRNA encodes the human telomerase reverse transcriptase (TERT) protein, a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.
Cat. No.: HY-122092
CAS No.: 247129-77-7
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Research Areas:
FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer .
Cat. No.: HY-P81110
Synonyms: telomerase catalytic subunit; EST2; hEST2; TCS1; telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; telomerase reverse transcriptase; telomerase Catalytic Subunit; telomerase-associated protein 2; TERT_human.
Cat. No.: HY-P81110A
Synonyms: telomerase catalytic subunit; EST2; hEST2; TCS1; telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; telomerase reverse transcriptase; telomerase Catalytic Subunit; telomerase-associated protein 2; TERT_human.
Cat. No.: HY-P704039
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TERT; telomerase Catalytic Subunit; telomerase Reverse Transcriptase; telomerase-Associated Protein 2; HEST2; PFBMFT1; TCS1; DKCA2; EST2; DKCB4; TRT; CMM9; TP2; HTRT
Cat. No.: HY-179480
Research Areas:
G-quadruplex ligand 4 is a chromenone derivative and is a human telomerase reverse transcriptase (hTERT) G4 ligand. G-quadruplex ligand 4 downregulates hTERT expression and exhibits notable cytotoxicity towards triple-negative breast cancer (TNBC) cell lines. G-quadruplex ligand 4 can cause S/G2 cell cycle arrest and induce apoptosis. G-quadruplex ligand 4 downregulates the expression of hTERT, KRAS, and BCL-2. G-quadruplex ligand 4 can be used for the research of TNBC .
Cat. No.: HY-P703632
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SCYL1; P105; Prev. NTKL; telomerase Transcriptional Elements-Interacting Factor; GKLP; Coated Vesicle-Associated Kinase Of 90 KDa; TAPK; SCY1-Like, Kinase-Like 1; TRAP; MGC78454; TEIF; Likely Ortholog Of Mouse N-Terminal Kinase-Like Protein; telomerase Re
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
