247129-77-7
247129-77-7
Chemical Structure
FJ-5002
- CAS 番号: 247129-77-7
- Formula:C20H22ClN3OS3
- Molecular Weight:452.06
IUPAC Name: 3-ethyl-2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-4-methylthiazol-3-ium chloride
InChIKey: DMINXLZXFAXHJM-KPJFUTMLSA-M
SMILES: CC1=CSC(/C=C(N(CC)C/2=O)\SC2=C3SC4=CC=CC=C4N\3C)=[N+]1CC.[Cl-]
Biological Activity: FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer[1][2].
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FJ-5002 | FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer. | |||||||||||||||||||||
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References
- [1]. Guo WZ, et al. Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines. Biol Pharm Bull. 2013;36(6):1008-16. [Content Brief]
- [2]. Naasani I, et al FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res. 1999 Aug 15;59(16):4004-11. [Content Brief]
