5 Results for "

intraperitoneal mouse models

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "intraperitoneal mouse models" in MCE Product Catalog:

Cat. No.: HY-P99925
CAS No.: 1192578-27-0
Synonyms: REGN421

Target:  

Notch

Domaines de recherche:  

Metabolic Disease Cancer

Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .
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Cat. No.: HY-N1884
CAS No.: 29424-96-2
Synonyms: (-)-Naringenin 4',​7-dimethyl Ether; (-)-NRG-DM
4',​7-​Di-​O-​methylnaringenin ((−)-NRG-DM) is a flavonoid found in Renealmia alpinia . (−)-NRG-DM inhibits Nav1.7, Nav1.8 and Kv2.1 channels and has analgesic activity. Intraperitoneal administration of (−)-NRG-DM dose-dependently attenuated pain in a formalin-induced mouse inflammatory pain model and mustard oil-induced mouse colorectal pain model[ 2].
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Cat. No.: HY-167108
CAS No.: 91635-05-1
Target:  

Drug Derivative

Domaines de recherche:  

Endocrinology

3-Glyoxyloylcoumarin is a Coumarin (HY-N0709) derivative with moderate to low acute toxicity. 3-Glyoxyloylcoumarin is applicable to studies on urinary system toxicity .
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Cat. No.: HY-184831
CAS No.: 462-73-7
Target:  

Drug Intermediate

Domaines de recherche:  

Others

1-Chloro-4-fluorobutane is an ω-fluoroalkyl halide and serves as a synthetic intermediate. 1-Chloro-4-fluorobutane exhibits acute toxicity in mice .
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Cat. No.: HY-181956
CAS No.: 312632-55-6
Target:  

Opioid Receptor

Domaines de recherche:  

Neurological Disease

MPAM-15 is a blood-brain barrier-penetrant pan-orthosteric allosteric modulator (PAM) of opioid receptors, with ≥16-fold selectivity for μOR over δOR and κOR. MPAM-15 acts as an anti-nociceptive potentiator and analgesic, and its activity is observed in mouse models via both intracerebroventricular and intraperitoneal administration. MPAM-15 is applicable for pain-related research .
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