Search Result

Results for "

let-7a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (2) Bcl-2 Family (2) Caspase (2) MicroRNA (22) Reference Standards (2) TGF-beta/Smad (2)
By Research Areas:	Cancer (19) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2)
Oligonucleotides:	miRNA mimics (5) miRNA antagomirs (5) miRNA agomirs (5) MicroRNAs (20) miRNA inhibitors (5)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6082

Rhein 8-O-β-D-Glucopyranoside 1 Publications Verification	Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial	Infection Metabolic Disease Inflammation/Immunology
Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

HY-R00003

*hsa-let-7a-5p mimic*	MicroRNA	Cancer
hsa-let-7a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-5p mimic hsa-let-7a-5p mimic

HY-RI00003

*hsa-let-7a-5p inhibitor*	MicroRNA	Cancer
hsa-let-7a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-5p inhibitor hsa-let-7a-5p inhibitor

HY-R00002

*hsa-let-7a-3p mimic*	MicroRNA	Cancer
hsa-let-7a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-3p mimic hsa-let-7a-3p mimic

HY-RI00001

*hsa-let-7a-2-3p inhibitor*	MicroRNA	Cancer
hsa-let-7a-2-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-2-3p inhibitor hsa-let-7a-2-3p inhibitor

HY-100692

*Lin28-let-7a* antagonist 1** 2 Publications Verification	MicroRNA	Cancer
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC₅₀ of 4.03 μM for Lin28A-let-7a-1 interaction.

HY-R00002A

*hsa-let-7a-3p agomir*	MicroRNA
hsa-let-7a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-3p agomir hsa-let-7a-3p agomir

HY-RI00002A

*hsa-let-7a-3p antagomir*	MicroRNA	Cancer
hsa-let-7a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-3p antagomir hsa-let-7a-3p antagomir

HY-RI00003A

*hsa-let-7a-5p antagomir*	MicroRNA	Cancer
hsa-let-7a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-5p antagomir hsa-let-7a-5p antagomir

HY-R00003A

*hsa-let-7a-5p agomir*	MicroRNA
hsa-let-7a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-5p agomir hsa-let-7a-5p agomir

HY-R00001A

*hsa-let-7a-2-3p agomir*	MicroRNA
hsa-let-7a-2-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-2-3p agomir hsa-let-7a-2-3p agomir

HY-RI02557A

*mmu-let-7a-1-3p antagomir*	MicroRNA	Cancer
mmu-let-7a-1-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7a-1-3p antagomir mmu-let-7a-1-3p antagomir

HY-R02558A

*mmu-let-7a-2-3p agomir*	MicroRNA	Cancer
mmu-let-7a-2-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7a-2-3p agomir mmu-let-7a-2-3p agomir

HY-RI00001A

*hsa-let-7a-2-3p antagomir*	MicroRNA	Cancer
hsa-let-7a-2-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-let-7a-2-3p antagomir hsa-let-7a-2-3p antagomir

HY-R02558

*mmu-let-7a-2-3p mimic*	MicroRNA	Cancer
mmu-let-7a-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7a-2-3p mimic mmu-let-7a-2-3p mimic

HY-R02557

*mmu-let-7a-1-3p mimic*	MicroRNA	Cancer
mmu-let-7a-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7a-1-3p mimic mmu-let-7a-1-3p mimic

HY-R00001

*hsa-let-7a-2-3p mimic*	MicroRNA	Cancer
hsa-let-7a-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-2-3p mimic hsa-let-7a-2-3p mimic

HY-RI02557

*mmu-let-7a-1-3p inhibitor*	MicroRNA	Cancer
mmu-let-7a-1-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7a-1-3p inhibitor mmu-let-7a-1-3p inhibitor

HY-N6082R

Rhein 8-O-β-D-Glucopyranoside (Standard)	Reference Standards Apoptosis Bacterial Bcl-2 Family Caspase TGF-beta/Smad	Infection Metabolic Disease Inflammation/Immunology
Rhein 8-O-β-D-Glucopyranoside (Standard) is the analytical standard of Rhein 8-O-β-D-Glucopyranoside (HY-N6083). This product is intended for research and analytical applications. Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .

HY-RI00002

*hsa-let-7a-3p inhibitor*	MicroRNA	Cancer
hsa-let-7a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-3p inhibitor hsa-let-7a-3p inhibitor

HY-R02557A

*mmu-let-7a-1-3p agomir*	MicroRNA	Cancer
mmu-let-7a-1-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7a-1-3p agomir mmu-let-7a-1-3p agomir

HY-RI02558A

*mmu-let-7a-2-3p antagomir*	MicroRNA	Cancer
mmu-let-7a-2-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7a-2-3p antagomir mmu-let-7a-2-3p antagomir

HY-RI02558

*mmu-let-7a-2-3p inhibitor*	MicroRNA	Cancer
mmu-let-7a-2-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7a-2-3p inhibitor mmu-let-7a-2-3p inhibitor

HY-100692R

*Lin28-let-7a* antagonist 1 (Standard)**	MicroRNA Reference Standards	Cancer
Lin28-let-7a antagonist 1 (Standard) is the analytical standard of Lin28-let-7a antagonist 1 (HY-100692). This product is intended for research and analytical applications. Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.

Cat. No.	Product Name	Category	Target	Chemical Structure