2. Epigenetics
  3. MicroRNA
  4. hsa-let-7a-2-3p antagomir

hsa-let-7a-2-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

For research use only. We do not sell to patients.

RNA, (GGAAAGCUAGGAGGCUGUAC) (2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification)

hsa-let-7a-2-3p antagomir Chemical Structure

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5 nmol USD 225 Get quote 1-2 weeks 1-2 weeks
20 nmol USD 560 Get quote 1-2 weeks 1-2 weeks
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Based on 1 publication(s) in Google Scholar

Other Forms of hsa-let-7a-2-3p antagomir:

hsa-let-7a-2-3p antagomir Related Antibodies

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Description

hsa-let-7a-2-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

Molecular Weight

7508.91

miRBase Accession Number
Mature miRNA Sequence

CUGUACAGCCUCCUAGCUUUCC

Stem-loop ID

hsa-let-7a-2

Stem-loop Sequence

AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU

Species

Human, Rat, Alligator mississippiensis, Anolis carolinensis, Chrysemys picta, Cricetulus griseus, Dasypus novemcinctus, Guinea pig, Monodelphis domestica, Ophiophagus hannah, Pteropus alecto, Rhesus monkey, Salmo salar

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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hsa-let-7a-2-3p antagomir Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hsa-let-7a-2-3p antagomirMicroRNAmiRNAInhibitorinhibitorinhibit

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