Lin28-let-7a antagonist 1
Based on 2 publication(s) in Google Scholar
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 2024548-03-4
- Formula: C31H29N5O7
- Molecular Weight:583.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Lin28-let-7a antagonist 1
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Biological Activity
IC50：4.03 μM (Lin28A-let-7a-1)[1].
Lin28-let-7a antagonist 1 (compound 1) shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM. Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency. Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA. When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2024548-03-4
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Appearance Solid
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Molecular Weight 583.59
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Formula C31H29N5O7
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Color Light yellow to yellow
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SMILES
O=C(O)C(C=C1)=CC=C1N2N=CC3=C2C4=CC([N+]([O-])=O)=C(N5CCN(C(OCC6=CC=CC=C6)=O)CC5)C=C4OC3(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Mol Cell
Genome-wide RNA structure changes during human neurogenesis modulate gene regulatory networks. [Abstract]2021 Dec 2;81(23):4942-4953.e8. PMID: 34655516 -
Oncogenesis
LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression. [Abstract]2022 Jul 2;11(1):37. PMID: 35780125
Solvent & Solubility
DMSO : 100 mg/mL (171.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7135 mL | 8.5677 mL | 17.1353 mL | 42.8383 mL |
| 5 mM | 0.3427 mL | 1.7135 mL | 3.4271 mL | 8.5677 mL | |
| 10 mM | 0.1714 mL | 0.8568 mL | 1.7135 mL | 4.2838 mL | |
| 15 mM | 0.1142 mL | 0.5712 mL | 1.1424 mL | 2.8559 mL | |
| 20 mM | 0.0857 mL | 0.4284 mL | 0.8568 mL | 2.1419 mL | |
| 25 mM | 0.0685 mL | 0.3427 mL | 0.6854 mL | 1.7135 mL | |
| 30 mM | 0.0571 mL | 0.2856 mL | 0.5712 mL | 1.4279 mL | |
| 40 mM | 0.0428 mL | 0.2142 mL | 0.4284 mL | 1.0710 mL | |
| 50 mM | 0.0343 mL | 0.1714 mL | 0.3427 mL | 0.8568 mL | |
| 60 mM | 0.0286 mL | 0.1428 mL | 0.2856 mL | 0.7140 mL | |
| 80 mM | 0.0214 mL | 0.1071 mL | 0.2142 mL | 0.5355 mL | |
| 100 mM | 0.0171 mL | 0.0857 mL | 0.1714 mL | 0.4284 mL |
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