7 Results for "

limb development

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "limb development" in MCE Product Catalog:

33
33 Cited Publications
Cat. No.: HY-16268
CAS No.: 4727-31-5
Synonyms: KGN
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
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33
33 Cited Publications
Cat. No.: HY-16268A
CAS No.: 1401168-39-5
Synonyms: KGN sodium
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
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Cat. No.: HY-135700
CAS No.: 19115-49-2
Purity:  ≥98.0%
Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (Ka = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .
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Cat. No.: HY-174702
Target:  

mRNA

Research Areas:  

Neurological Disease

Human FGF2 mRNA encodes the human fibroblast growth factor 2 (FGF2) protein, a member of the fibroblast growth factor (FGF) family. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth.
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Cat. No.: HY-174477
Target:  

mRNA

Research Areas:  

Cardiovascular Disease

Mouse Tbx5 mRNA encodes the mouse T-box 5 (Tbx5) protein, a DNA-binding protein that regulates the transcription of several genes. Tbx5 is involved in heart development and limb pattern formation.
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Cat. No.: HY-174554
Target:  

mRNA

Research Areas:  

Cancer

Human PAX9 mRNA encodes the human paired box 9 (PAX9) protein, a member of the paired box (PAX) family. PAX9 is required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
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Cat. No.: HY-174538
Target:  

mRNA

Research Areas:  

Cardiovascular Disease

Human TBX5 mRNA encodes the human T-box transcription factor 5 (TBX5) protein, a member of a phylogenetically conserved family. TBX5 is a DNA-binding protein that regulates the transcription of several genes and also involved in heart development and limb pattern formation.
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