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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
lipid order
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "lipid order" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-D1428
CAS No.: 797785-10-5
Cat. No.: HY-162160
CAS No.: 1221739-85-0
Cat. No.: HY-W800805
CAS No.: 2295813-15-7
DOPE-Mal is an N-maleimide-derived phosphatidylethanolamine. DOPE-Mal does not interfere with fatty acyl chains or alter lipid bilayer permeability; it increases lipid bilayer order, reduces fluidity, induces conformational changes in phospholipid polar heads and enhances their hydration. DOPE-Mal can be used as a component to prepare maleimide-displaying liposomes, enabling peptide conjugation via maleimide-thiol coupling. DOPE-Mal can be used to prepare Liposomes for delivering Doxorubicin (HY-15142A) to hepatocytes. DOPE-Mal is applicable to research related to hepatocellular carcinoma and lung cancer .
Cat. No.: HY-D3093
CAS No.: 2757682-02-1
Target:
Research Areas:
NRERcl is a Golgi-targeting lipid order probe. NRERcl can be used for imaging the lipid order and polarity of the endoplasmic reticulum. NRERcl carries a propyl chloride targeting group that directs it to the endoplasmic reticulum, and it functions via excited-state charge transfer, emitting colors according to local polarity changes associated with lipid order. NRERcl partitions into lipid membranes, with a higher fluorescence quantum yield in membrane environments than in aqueous buffers; its excitation wavelength is 520 nm, and the emission maximum varies with the environment (Ex/Em = 520/584-653 nm) .
Cat. No.: HY-D3091
CAS No.: 2757681-99-3
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Research Areas:
NRLyso is a lysosome-targeted solvatochromic fluorescent probe derived from Nile Red (HY-D0718). It can localize to lysosomes and is applicable for imaging lysosomal lipid order and polarity. The excitation wavelength of NRLyso is 520 nm, and its emission maximum varies with the environment. NRLyso partitions well into lipid membranes: it exhibits fluorescence enhancement and emission blue-shift in low-polarity, tightly packed lipid environments, while shows emission red-shift in more polar, disordered lipid environments. NRLyso maintains organelle specificity under oxidative and hyperosmotic stress conditions, and can detect changes in lysosomal lipid order and polarity in response to these stresses, cholesterol extraction, and cholesterol enrichment .
Cat. No.: HY-D3092
CAS No.: 2757682-01-0
Target:
Research Areas:
NRERf is an endoplasmic reticulum (ER)-targeted solvatochromic fluorescent probe based on Nile Red (HY-D0718). It possesses ER-targeting capability and can sense changes in local polarity and lipid order of biological membranes. NRERf undergoes excited-state charge transfer, with its emission color changing according to local polarity: the tightly packed, low-polarity liquid-ordered phase (Lo) induces a blue-shifted emission, while the high-polarity liquid-disordered phase (Ld) induces a red-shifted emission. The emission wavelength of NRERf varies with the environment. NRERf can be used to detect changes in lipid order and polarity induced in the ER by cholesterol extraction/enrichment, oxidative stress, and hyperosmotic shock .
Cat. No.: HY-DY1089
CAS No.: 797785-10-5
Solvent and concentration: DMSO: 5 mM
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
