1221739-85-0
1221739-85-0
Chemical Structure
NR12S
- CAS No.: 1221739-85-0
- Formula:C39H57N3O6S
- Molecular Weight:695.95
InChIKey: MJGSHKTVWQIWAA-UHFFFAOYSA-N
SMILES: O=C1C=C2OC3=C(N=C2C4=CC(OCCC[N+](CCCCCCCCCCCC)(CCCS(=O)([O-])=O)C)=CC=C14)C=CC(N(CC)CC)=C3
Biological Activity: NR12S is a fluorescent probe that specifically binds to the outer leaflet of membranes. NR12S exhibits phase-sensitive red edge excitation shift, emission wavelength shift and lifetime changes, which depend on membrane phase, cholesterol content and lipid acyl chain properties. NR12S can be used to study cholesterol and lipid order in biological membranes[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NR12S | 98.75% | NR12S is a fluorescent probe that specifically binds to the outer leaflet of membranes. NR12S exhibits phase-sensitive red edge excitation shift, emission wavelength shift and lifetime changes, which depend on membrane phase, cholesterol content and lipid acyl chain properties. NR12S can be used to study cholesterol and lipid order in biological membranes. | ||||||||||||||||||||
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References
- [1]. Kucherak OA, et al. Switchable nile red-based probe for cholesterol and lipid order at the outer leaflet of biomembranes. Journal of the American Chemical Society. 2010 Apr 07;132(13):4907-16. [Content Brief]
- [2]. Saxena R, et al. Location, dynamics and solvent relaxation of a Nile Red-based phase-sensitive fluorescent membrane probe. Chemistry and physics of lipids. 2014 Oct;183:1-8.
- [3]. Ragaller F, et al. Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements. The journal of physical chemistry. B. 2024 Mar 07;128(9):2154-2167.
- [4]. Darwich Z, et al. Detection of apoptosis through the lipid order of the outer plasma membrane leaflet. Biochimica et biophysica acta. 2012 Dec;1818(12):3048-54.
- [5]. Darwich Z, Klymchenko AS, Dujardin D, Mély Y. Imaging lipid order changes in endosome membranes of live cells by using a Nile Red‑based membrane probe. RSC Adv. 2014 Mar 13;4(17):8481‑8488.
- [6]. Pyrshev KA, et al. Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. Biochimica et biophysica acta. Biomembranes. 2017 Oct;1859(10):2123-2132.
- [7]. Kreder R, et al. Solvatochromic Nile Red probes with FRET quencher reveal lipid order heterogeneity in living and apoptotic cells. ACS chemical biology. 2015 Jun 19;10(6):1435-42.
- [8]. Saxena R, et al. Cholesterol-induced changes in hippocampal membranes utilizing a phase-sensitive fluorescence probe. Biochimica et biophysica acta. 2015 Aug;1848(8):1699-705.
